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Titolo:
CULTURED PERIPHERAL-BLOOD MONONUCLEAR LEUKOCYTES FROM ANOREXIA-NERVOSA PATIENTS ARE REFRACTORY TO VISIBLE-LIGHT
Autore:
FINOCCHIARO LME; POLACK E; NAHMOD VE; GLIKIN GC;
Indirizzi:
UNIV BUENOS AIRES,INST INVEST MED,SUSTANCIAS VASOACT LAB,DONATO ALVAREZ 3150 RA-1427 BUENOS AIRES DF ARGENTINA UNIV BUENOS AIRES,FAC CIENCIAS EXACTAS & NAT,CONSEJO NACL INVEST CIENT & TECN RA-1428 BUENOS AIRES DF ARGENTINA
Titolo Testata:
Life sciences
fascicolo: 6, volume: 57, anno: 1995,
pagine: 559 - 569
SICI:
0024-3205(1995)57:6<559:CPMLFA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEASONAL AFFECTIVE-DISORDER; INTERFERON-GAMMA; MELATONIN BIOSYNTHESIS; EATING DISORDERS; CELLS; SEROTONIN; PINEAL; INDOLEAMINES; HYPOTHESIS; METABOLISM;
Keywords:
PERIPHERAL BLOOD MONONUCLEAR LEUKOCYTES; SEROTONIN; MELATONIN; VISIBLE LIGHT; ANOREXIA NERVOSA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
L.M.E. Finocchiaro et al., "CULTURED PERIPHERAL-BLOOD MONONUCLEAR LEUKOCYTES FROM ANOREXIA-NERVOSA PATIENTS ARE REFRACTORY TO VISIBLE-LIGHT", Life sciences, 57(6), 1995, pp. 559-569

Abstract

Cultured human peripheral blood mononuclear leukocytes [PBML] from patients with anorexia nervosa [An] did;not respond to light stimulationas PBML of normal controls [NC] did. During winter, visible light increased [H-3]thymidine incorporation into DNA of NC-PBML stimulated with phytohemagglutinin [PHA]. This effect was enhanced by 10(-7) M melatonin. PHA-stimulated DNA synthesis of PBML from AN patients failed to respond to photic stimulation during winter, and their proliferative response to melatonin was significantly blunted. In vitro photic stimulation of NC-PBML reduced melatonin while increasing both serotonin and5-hydroxyindole 3-acetic acid [HIAA] production in both basal and PHA-stimulated conditions. In contrast AN-PBML, that in darkness enhancedthe oxidative deamination of serotonin into HIAA more than NC-PBML, did not switch their indole metabolism in response to light. Light did not inhibit the binding of both melatonin and serotonin to AN-PBML as occurred in NC-PBML. The present data suggest that AN-PBML do not respond to light in vitro, because of a failure in the regulation of serotonin and melatonin metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:09:28