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Titolo:
DIFFERENTIAL-EFFECTS OF MIDAZOLAM AND ZOLPIDEM ON SLEEP-WAKE STATES AND EPILEPTIC ACTIVITY IN WAG RIJ RATS/
Autore:
DEPOORTERE H; FRANCON D; VANLUIJTELAAR ELJM; DRINKENBURG WHIM; COENEN AML;
Indirizzi:
SYNTHELABO RECH LERS,31 AVE PAUL VAILLANT COUTURIER F-92220 BAGNEUX FRANCE UNIV NIJMEGEN,NICI,DEPT PSYCHOL NIJMEGEN NETHERLANDS
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 51, anno: 1995,
pagine: 571 - 576
SICI:
0091-3057(1995)51:4<571:DOMAZO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABSENCE EPILEPSY; BENZODIAZEPINE RECEPTORS; REBOUND INSOMNIA; ABECARNIL; STRAIN; EEG;
Keywords:
SLEEP-WAKE STATES; SPIKE-WAVE DISCHARGES; ABSENCE EPILEPSY; MIDAZOLAM; ZOLPIDEM; HYPNOTICS; WAG/RIJ STRAIN; RATS; REBOUND EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
H. Depoortere et al., "DIFFERENTIAL-EFFECTS OF MIDAZOLAM AND ZOLPIDEM ON SLEEP-WAKE STATES AND EPILEPTIC ACTIVITY IN WAG RIJ RATS/", Pharmacology, biochemistry and behavior, 51(4), 1995, pp. 571-576

Abstract

Hypnotic drugs are known to possess antiepileptic activity. Therefore, the effects of the benzodiazepine hypnotic midazolam (10 mg/kg) and the novel imidazopyridine hypnotic zolpidem (10 mg/kg) on sleep-wake states and on the number of spike-wave discharges were evaluated in WAG/Rij rats. Rats of this strain are considered to be a model for generalized absence epilepsy. Animals were implanted with chronic monopolar EEG electrodes and, after recovery from surgery, the EEG was recorded for 6 h during the dark period on 3 consecutive days. Sleep recordingswere analyzed using Hjorth's parameters and number and duration of spike-wave discharges were visually determined. It was found that both drugs facilitated nonREM sleep at the cost of wakefulness. Both hypnotics also reduced the number and duration of spike-wave discharges. The initial decrease after midazolam, however, was followed by a rebound reflecting a poorer quality of vigilance expressed as an increase in spike-wave discharges. The strong antiabsence activity of zolpidem mimics that of midazolam and is well correlated with their equipotent hypnotic action and anticonvulsant effect in the isoniazid test.

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Documento generato il 24/09/20 alle ore 05:27:20