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Titolo:
MONITORING ALLERGEN EXPOSURE IN ASTHMA - NEW TREATMENT STRATEGIES
Autore:
CHAPMAN MD; HEYMANN PW; SPORIK RB; PLATTSMILLS TAE;
Indirizzi:
UNIV VIRGINIA,CTR ASTHMA & ALLERG DIS,DEPT MED CHARLOTTESVILLE VA 22908
Titolo Testata:
Allergy
fascicolo: 25, volume: 50, anno: 1995, supplemento:, S
pagine: 29 - 33
SICI:
0105-4538(1995)50:25<29:MAEIA->2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOUSE-DUST MITE; PARTICLE-SIZE DISTRIBUTION; AIRBORNE CAT ALLERGEN; FEL-D-I; ENVIRONMENTAL EXPOSURE; RISK-FACTORS; P-I; SENSITIZATION; CHILDREN; DERMATOPHAGOIDES;
Keywords:
ALLERGEN; ASTHMA; TREATMENT; MONITORING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Chapman et al., "MONITORING ALLERGEN EXPOSURE IN ASTHMA - NEW TREATMENT STRATEGIES", Allergy, 50(25), 1995, pp. 29-33

Abstract

The development of monoclonal antibody-based enzyme-linked immunosorbent assay technology for measuring environmental allergen exposure hasprovided a benchmark for assessing the role of indoor allergens in causing asthma and other allergic diseases. Epidemiological studies fromseveral parts of the world have shown that immunoglobulin E (IgE)-mediated sensitization to indoor allergens (mite, cat, dog and cockroach)is a risk factor for asthma attacks. A dose-response relationship between allergen exposure and sensitization has been demonstrated for mite allergens, and threshold values for exposure levels leading to sensitization or to exacerbations of symptoms have been defined. Comparative studies on airborne allergen levels have made it possible to determine the properties of aeroallergen particles, their concentration in indoor air, and the relationship to clinical symptoms. Together, these studies provide strong evidence that allergen exposure plays a causal role in the development of bronchial hyperreactivity and of the chronicinflammatory responses seen in patients with asthma. Logically, the primary preventive treatment should be allergen avoidance. Through knowledge of indoor allergen levels, both in dust and in the air, different avoidance strategies have been applied to the various indoor allergens, and there is increasing evidence of their clinical efficacy. Monitoring allergen levels in patients' houses should improve their understanding of the role of allergens in asthma and improve compliance with avoidance measures.

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Documento generato il 02/06/20 alle ore 03:24:04