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Titolo:
ANTIGEN-SPECIFIC LYMPHOPROLIFERATIVE RESPONSES TO TETANUS TOXOID - A MEANS FOR THE EVALUATION OF MAREKS-DISEASE VIRUS-INDUCED IMMUNOSUPPRESSION IN CHICKENS
Autore:
REDDY SK; SURESH M; KARACA K; SHARMA JM; MCMILLEN J; SCHWARTZ RD;
Indirizzi:
RHONE MERIEUX INC,115 TRANSTECH DR ATHENS GA 30601 UNIV MINNESOTA,COLL VET MED ST PAUL MN 55108 SYNTROVET INC LENEXA KS 66219 HOECHST ROUSSEL PHARMACEUT PROPRIETARY LTD SOMERVILLE NJ 08876
Titolo Testata:
Vaccine
fascicolo: 17-18, volume: 14, anno: 1996,
pagine: 1695 - 1702
SICI:
0264-410X(1996)14:17-18<1695:ALRTTT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HERPES-SIMPLEX VIRUS; INFECTION; INHIBITION; IMMUNITY; EFFICACY; VACCINES;
Keywords:
TETANUS TOROID; ANTIGENIC PROLIFERATION ASSAY; PHA-P; RECOMBINANT HERPESVIRUS OF TURKEYS; FUSION AND HEMAGGLUTININ-NEURAMINIDASE OF NEWCASTLE DISEASE VIRUS; GLYCOPROTEIN A, B AND D OF MAREKS DISEASE VIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
S.K. Reddy et al., "ANTIGEN-SPECIFIC LYMPHOPROLIFERATIVE RESPONSES TO TETANUS TOXOID - A MEANS FOR THE EVALUATION OF MAREKS-DISEASE VIRUS-INDUCED IMMUNOSUPPRESSION IN CHICKENS", Vaccine, 14(17-18), 1996, pp. 1695-1702

Abstract

Antigen-specific lymphoproliferative responses were examined in chickens following immunization with tetanus toroid (Ttx). The immune competence of chickens was assessed by mitogen assay utilizing phytohemagglutinin (PHA)-stimulation and Ttx-specific antigen proliferation assay (Ttx-APA). Immune spleen cells but not peripheral blood leucocytes demonstrated specific proliferation following stimulation in vitro in a Ttx-APA. In this study, we examined firstly the effects of Marek's disease (MD)associated immunosuppression on specific immune responses. Thehumoral and cell-mediated immune responses were monitored by enzyme-linked immunosorbent assay (ELISA) and Ttx-APA, respectively. Secondly,we examined if vaccination against MD using a conventional herpesvirus of turkeys (HVT) vaccine and two recombinant HVT (rHVT) vaccines would affect the development of Ttx-specific immune responses. The rHVT vaccines used in this study included two constructs: one expressing both Newcastle disease virus (NDV) and MD virus (MDV) genes (HVT/NDV/MDV), and another expressing only MDV genes (HVT/MDV). The mitogenic responses of spleen cells of the vaccinated chickens were inconsistent allowing no definitive conclusions about vaccinal immunosuppression. The results of the Ttx-APA indicated that Ttx-specific lymphoproliferative responses provide a meaningful measure of immunosuppression. The MDV-induced immunosuppression resulted in the inhibition of Ttx-specific lymphoproliferation in vitro. Both HVT and rHVT vaccines were not immunosuppressive as indicated by the development of normal Ttx-specific lymphoproliferative responses in chickens. These results indicate that vaccination against MD results not only in the prevention of tumor formation but also protection from possible virus-induced immunosuppression. Published by Elsevier Science Ltd.

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Documento generato il 04/07/20 alle ore 23:23:04