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Titolo:
RESPONSES OF FERRET LOWER ESOPHAGEAL SPHINCTER TO 5-HYDROXYTRYPTAMINE- PATHWAYS AND RECEPTOR SUBTYPES
Autore:
BLACKSHAW LA; NISYRIOS V; DENT J;
Indirizzi:
ROYAL ADELAIDE HOSP,GASTROENTEROL UNIT,N TERRACE ADELAIDE SA 5000 AUSTRALIA
Titolo Testata:
American journal of physiology: Gastrointestinal and liver physiology
fascicolo: 6, volume: 31, anno: 1995,
pagine: 1004 - 1011
SICI:
0193-1857(1995)31:6<1004:ROFLES>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROESOPHAGEAL REFLUX; ANESTHETIZED FERRET; ANTAGONISM; 5-HT; PHARMACOLOGY; INNERVATION; RELAXATIONS; DRUG; DOG;
Keywords:
5-HYDROXYTRYPTAMINE(3) RECEPTOR; 5-HYDROXYTRYPTAMINE(2) RECEPTOR; VAGUS NERVES; SPLANCHNIC NERVES; LOWER ESOPHAGEAL SPHINCTER RELAXATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
L.A. Blackshaw et al., "RESPONSES OF FERRET LOWER ESOPHAGEAL SPHINCTER TO 5-HYDROXYTRYPTAMINE- PATHWAYS AND RECEPTOR SUBTYPES", American journal of physiology: Gastrointestinal and liver physiology, 31(6), 1995, pp. 1004-1011

Abstract

In urethan-anesthetized ferrets, basal lower esophageal sphincter pressure (LESP) was unaffected by the 5-hydroxytryptamine(3) (5-HT3) receptor antagonist granisetron (0.5 mg/kg) or by greater splanchnic nervesection (GSX), but increased after bilateral vagotomy. Peripheral vagal nerve stimulation caused LES relaxation, often followed by a brief contraction and a prolonged inhibition of LESP. Close intra-arterial injection of 5-HT (5-100 mu g) had a biphasic effect on LESP, with a brief drop followed by a prolonged increase. Granisetron (0.5 mg/kg iv) abolished the initial relaxation and revealed an earlier peak of excitation. This was not influenced by subsequent vagotomy and GSX. In a series of eight additional experiments (series 2), granisetron was givenafter vagotomy and GSX. In series 2, 5-HT-induced relaxation was unaffected by vagotomy but was significantly reduced after GSX and was further reduced after granisetron, indicating that 5-HT3 receptor mechanisms may lie on a sympathetic neural pathway. Vagotomy had no effect onthe excitatory component. GSX had no effect on the amplitude of excitation, but reduced its latency. Granisetron had no further effect on excitation in series 2. In a separate series of 13 experiments (series 3), the excitatory component of the LES response to 5-HT was abolishedby ketanserin (2.5 mg/kg iv), after which only relaxation occurred. Both 5-HT2 and 5-HT3 antagonists in combination abolished all effects of 5-HT on LESP. Atropine (400 mu g/kg iv, n = 7) had no effect on 5-HT-induced LES responses. Guanethidine (5 mg/kg iv, n = 7) had similar effects to GSX. An alternative 5-HT3 receptor antagonist, BRL-46470 (0.5 mg/kg), had no effect on 5-HT-induced LES responses (n = 5), indicating that a specific subtype of 5-HT3 receptor is involved in reductionof LESP by 5-HT.

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Documento generato il 01/10/20 alle ore 00:32:41