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Titolo:
ENHANCEMENT OF COMPUTED-TOMOGRAPHY LIVER CONTRAST USING IOMEPROL-CONTAINING LIPOSOMES AND DETECTION OF SMALL LIVER-TUMORS IN RATS
Autore:
FOUILLET X; TOURNIER H; KHAN H; SABITHA S; BURKHARDT S; TERRIER F; SCHNEIDER M;
Indirizzi:
BRACCO RES SA,7 ROUTE DRIZE CH-1227 CAROUGE SWITZERLAND UNIV GENEVA,CANTONAL HOSP,DEPT RADIOL GENEVA SWITZERLAND
Titolo Testata:
Academic radiology
fascicolo: 7, volume: 2, anno: 1995,
pagine: 576 - 583
SICI:
1076-6332(1995)2:7<576:EOCLCU>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMAGING RESEARCH; 1'-HYDROXYSAFROLE; CANCER; MODEL; CT; CARCINOMA; SAFROLE;
Keywords:
IOMEPROL; LIPIOM; LIPOSOMES; HEPATOCELLULAR CARCINOMAS; RATS; INDUCED TUMORS; COMPUTED TOMOGRAPHY SCANNING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
X. Fouillet et al., "ENHANCEMENT OF COMPUTED-TOMOGRAPHY LIVER CONTRAST USING IOMEPROL-CONTAINING LIPOSOMES AND DETECTION OF SMALL LIVER-TUMORS IN RATS", Academic radiology, 2(7), 1995, pp. 576-583

Abstract

Rationale and Objectives. We evaluated iomeprol-containing liposomes (Lipiom), a new contrast medium for computed tomography (CT) liver scanning, in an animal model of chemically induced hepatocellular carcinomas and other liver tumors in rats. Methods. Liver tumors were inducedby administration of carcinogens to rats, either 0.55% (w/w) 1'-hydroxysafrole in the diet or induction by 3'-methyl-4-diethylaminoazobenzene followed by promotion with carbon tetrachloride. CT scanning was performed 1-3 hr after intravenous injection of iomeprol-containing liposomes. Results. After injection of iomeprol-containing liposomes at a dose of 70 mg of liposome-entrapped iodine per kilogram of body weight, the normal liver parenchyma showed a contrast enhancement, in Hounsfield units, of more than 60% over the control value before bolus. Liver tumors with no or few Kupffer cells were not enhanced and appeared as dark areas within the normal parenchyma. Tumors and pretumoral lesions devoid of Kupffer cells, as small as 3 mm in diameter, could be distinguished using this noninvasive method. Conclusion. CT liver scanning after injection of iomeprol-containing liposomes appears to be a promising method for detecting liver tumors and focal liver lesions.

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Documento generato il 09/07/20 alle ore 13:31:23