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Titolo:
MAGNETIC-RESONANCE-IMAGING WITH SUPERPARAMAGNETIC IRON-OXIDE PARTICLES TO EVALUATE HEPATIC MACROPHAGE-MONOCYTIC PHAGOCYTOSIS AFTER ARTERIALDEVASCULARIZATION IN MINIPIGS
Autore:
TERRIER F; TOURNIAIRE J; BELENGER J; SLOSMAN D; RUBBIA L; GROSSHOLZ M; MENTHA G; HILTBRAND E; MERMILLOD B;
Indirizzi:
HOP CANTONAL UNIV GENEVA,DIV RADIODIAGNOST CH-1211 GENEVA 14 SWITZERLAND UNIV GENEVA,DEPT RADIOL GENEVA SWITZERLAND UNIV GENEVA,DEPT ANESTHESIOL GENEVA SWITZERLAND UNIV GENEVA,DEPT PATHOL CH-1211 GENEVA SWITZERLAND UNIV GENEVA,DEPT SURG GENEVA SWITZERLAND UNIV GENEVA,CR INFORMAT HOSP GENEVA SWITZERLAND
Titolo Testata:
Academic radiology
fascicolo: 7, volume: 2, anno: 1995,
pagine: 565 - 575
SICI:
1076-6332(1995)2:7<565:MWSIP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MR CONTRAST AGENT; RETICULOENDOTHELIAL SYSTEM; CLINICAL-APPLICATION; HEPATOCYTE FUNCTION; FERRITE PARTICLES; RAT-LIVER; PHARMACOKINETICS; CIRRHOSIS; DTPA;
Keywords:
MAGNETIC RESONANCE IMAGING; SUPERPARAMAGNETIC IRON OXIDE PARTICLES; HEPATIC MACROPHAGE-MONOCYTIC PHAGOCYTIC SYSTEM; RETICULOENDOTHELIAL SYSTEM; ISCHEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
F. Terrier et al., "MAGNETIC-RESONANCE-IMAGING WITH SUPERPARAMAGNETIC IRON-OXIDE PARTICLES TO EVALUATE HEPATIC MACROPHAGE-MONOCYTIC PHAGOCYTOSIS AFTER ARTERIALDEVASCULARIZATION IN MINIPIGS", Academic radiology, 2(7), 1995, pp. 565-575

Abstract

Rationale and Objectives. We examined the effects of arterial ischemia on the phagocytic activity of the hepatic macrophage-monocytic phagocytic system (MMPS). Methods. Six minipigs were studied before and 24 hr after complete arterial devascularization of the liver. Magnetic resonance (MR) imaging was performed at 1.5 T using superparamagnetic iron oxide (SPIO) particles (18 mu mol Fe/kg body weight) as an MMPS-specific contrast agent. Hepatobiliary scintigraphy, measurements of serum liver enzymes, and histology also were obtained. Results. On MR imaging, the postcontrast-to-precontrast ratios of the arterially devascularized livers were significantly higher than the corresponding baseline values (p < .01). The greatest difference (52%) between the baselineand the postoperative values was observed on gradient-echo (GE) images. Scintigraphy, laboratory analyses, and histology results indicate that the MR imaging findings were probably predominantly attributable to a reduction in phagocytic activity of the hepatic MMPS. Conclusion. SPIO particles have already proved useful for improving detection of liver neoplasms on MR imaging, but they also may provide a novel way ofevaluating the function of the hepatic MMPS in liver diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 05:18:16