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Titolo:
EFFECTS OF COMPLETE AND PARTIAL LESIONS OF THE DOPAMINERGIC MESOTELENCEPHALIC SYSTEM ON SKILLED FORELIMB USE IN THE RAT
Autore:
BARNEOUD P; PARMENTIER S; MAZADIER M; MIQUET JM; BOIREAU A; DUBEDAT P; BLANCHARD JC;
Indirizzi:
RHONE POULENC RORER SA,CTR RECH VITRY ALFORTVILLE,DEPT BIOL,13 QUAI JULES GUESDE F-94403 VITRY FRANCE
Titolo Testata:
Neuroscience
fascicolo: 4, volume: 67, anno: 1995,
pagine: 837 - 848
SICI:
0306-4522(1995)67:4<837:EOCAPL>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANTIA-NIGRA; NIGROSTRIATAL DOPAMINE; STRIATAL GRAFTS; ROTATIONAL BEHAVIOR; DENERVATED STRIATUM; BASIC IMPLICATIONS; REACHING DEFICITS; MOTOR ASYMMETRY; LIMB USE; RECOVERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
P. Barneoud et al., "EFFECTS OF COMPLETE AND PARTIAL LESIONS OF THE DOPAMINERGIC MESOTELENCEPHALIC SYSTEM ON SKILLED FORELIMB USE IN THE RAT", Neuroscience, 67(4), 1995, pp. 837-848

Abstract

This study compares certain behavioural consequences of partial and complete unilateral lesions of the dopaminergic mesotelencephalic system. We investigated skilled forelimb use, rotations induced by apomorphine and amphetamine, and dopaminergic metabolism of the nigrostriatal system of rats that had received a unilateral injection of 6-hydroxydopamine into the medial forebrain bundle. The rats classified Apo(+), that rotated after the administration of apomorphine, had a complete lesion of the nigrostriatal system, whereas those classified Apo(-), that did not rotate after the administration of apomorphine, had a partial lesion of the nigrostriatal system. In the Apo(+) rats, 99.8% of thedopamine in the striatum was depleted, as was 85% of that in the substantia nigra. For the Apo(-) rats, 72% of the dopamine in the striatumwas depleted as was 56% of that in the substantia nigra. When investigated with the staircase test, the animals with the most severe dopamine depletions were those most impaired in the paw reaching task. Complete and partial unilateral depletions of the dopaminergic mesotelencephalic system impaired the hierarchic phases of paw reaching differently. A complete dopamine depletion, but not a partial one, decreased thenumber of attempts made with the contralateral paw, and induced a bias towards the ipsilateral paw. A partial dopamine lesion impaired the sensorimotor co-ordination of both paws, whereas the complete dopaminelesion had a greater effect on the contralateral paw than on the ipsilateral paw. The mild paw reaching impairments observed in animals with moderate depletions of dopamine are proposed as a model of the earlysymptoms of Parkinson's disease that may be useful for the development of protective or restorative therapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:46:00