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Titolo:
DETECTION OF ANTI-CHLAMYDIA PNEUMONIAE IGE IN CHILDREN WITH REACTIVE AIRWAY DISEASE
Autore:
EMRE U; SOKOLOVSKAYA N; ROBLIN PM; SCHACHTER J; HAMMERSCHLAG MR;
Indirizzi:
SUNY HLTH SCI CTR,DEPT PEDIAT,BOX 49,450 CLARKSON AVE BROOKLYN NY 11203 SUNY HLTH SCI CTR,DEPT PEDIAT BROOKLYN NY 11203 UNIV CALIF SAN FRANCISCO,DEPT LAB MED SAN FRANCISCO CA 94143
Titolo Testata:
The Journal of infectious diseases
fascicolo: 1, volume: 172, anno: 1995,
pagine: 265 - 267
SICI:
0022-1899(1995)172:1<265:DOAPII>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS-SPECIFIC IGE; INFECTION; PRECIPITANTS; ASTHMA;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
U. Emre et al., "DETECTION OF ANTI-CHLAMYDIA PNEUMONIAE IGE IN CHILDREN WITH REACTIVE AIRWAY DISEASE", The Journal of infectious diseases, 172(1), 1995, pp. 265-267

Abstract

An association of Chlamydia pneumoniae infection and reactive airway disease has been demonstrated in children. To determine if C. pneumoniae infection triggers production of C. pneumoniae-specific IgE, sera were examined from 45 children with and without C. pneumoniae infection. Anti-C. pneumoniae IgE was demonstrated by immunoblotting in 12 (85.7%) of 14 culture-positive asthmatic patients with wheezing compared with only 1 (9.1%) of 11 culture-positive patients with pneumonia, 2 (18.2%) of 11 culture-negative asthmatic children with wheezing, and 2 (22.2%) of 9 culture-negative asymptomatic patients. The most commonly recognized proteins were at 98 (82.4%), 78 (58.8%), 58-60 (70.6%), and36 kDa (64.7%). The presence of anti-C. pneumoniae IgE by immunoblotting was not associated with the presence of anti-C. pneumoniae IgG andIgM by microimmunofluorescence. These results suggest that productionof specific IgE may be an underlying mechanism leading to reactive airway disease in some patients with C. pneumoniae infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 12:21:53