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Titolo:
ENDOCRINE AND EXOCRINE PANCREATIC FUNCTION AFTER CAMOSTATE-INDUCED GROWTH OF THE ORGAN
Autore:
VONSCHONFELD J; RUNZI M; GOEBELL H; MULLER MK;
Indirizzi:
UNIV ESSEN CLIN,MED CLIN,DEPT GASTROENTEROL,HUFELANDSTR 55 D-45122 ESSEN GERMANY UNIV CLIN MANNHEIM,MED CLIN 4 MANNHEIM GERMANY
Titolo Testata:
Experientia
fascicolo: 6, volume: 51, anno: 1995,
pagine: 556 - 560
SICI:
0014-4754(1995)51:6<556:EAEPFA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT PANCREAS; TRYPSIN-INHIBITOR; CCK ANTAGONIST; ACINAR AXIS; CHOLECYSTOKININ; SECRETION; SOMATOSTATIN; CERULEIN; SENSITIVITY; L-364,718;
Keywords:
CAMOSTATE; ENDOCRINE AND EXOCRINE PANCREAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J. Vonschonfeld et al., "ENDOCRINE AND EXOCRINE PANCREATIC FUNCTION AFTER CAMOSTATE-INDUCED GROWTH OF THE ORGAN", Experientia, 51(6), 1995, pp. 556-560

Abstract

In rats, daily administration of 200 mg camostate/kg b. wt for 14 days significantly increased pancreatic weight and pancreatic content of DNA, protein, amylase, lipase, trypsin and chymotrypsin, as well as the amount of insulin, glucagon and somatostatin. In the intact animal, blood glucose levels and serum concentrations of insulin and glucagon in response to an oral glucose load were not impaired after camostate treatment. In the isolated perfused pancreas, however, insulin and glucagon secretions were reduced, whereas somatostatin release was not affected. The volume of pancreatic juice produced by the unstimulated isolated perfused organ, as well as protein and enzyme secretion, were increased after camostate treatment. Likewise, the isolated perfused pancreas from camostate-treated rats secreted a larger volume of pancreatic juice and more protein in response to cholecystokinin (CCK), whileenzyme secretion was affected in a non-parallel manner: amylase release was markedly reduced, lipase release was unchanged, and release of trypsin and chymotrypsin was increased.

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Documento generato il 05/12/20 alle ore 20:21:17