Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE STRUCTURE OF THE APLYSIA-KURODAI GENE ENCODING ADP-RIBOSYL CYCLASE, A 2ND-MESSENGER ENZYME
Autore:
NATA K; SUGIMOTO T; TOHGO A; TAKAMURA T; NOGUCHI N; MATSUOKA A; NUMAKUNAI T; SHIKAMA K; YONEKURA H; TAKASAWA S; OKAMOTO H;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT BIOCHEM,AOBA KU,2-1 SEIRYO MACHI SENDAI MIYAGI 98077 JAPAN TOHOKU UNIV,SCH MED,DEPT BIOCHEM,AOBA KU SENDAI MIYAGI 98077 JAPAN TOHOKU UNIV,FAC SCI,INST BIOL SENDAI MIYAGI 98077 JAPAN TOHOKU UNIV,ASAMUSHI MARINE BIOL STN ASAMUSHI AOMORI 03934 JAPAN
Titolo Testata:
Gene
fascicolo: 2, volume: 158, anno: 1995,
pagine: 213 - 218
SICI:
0378-1119(1995)158:2<213:TSOTAG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EGG-SPECIFIC NADASE; SEA-URCHIN EGGS; INOSITOL TRISPHOSPHATE; 2ND-MESSENGER ENZYME; CYCLIC METABOLITE; CALCIUM-RELEASE; ANTIGEN CD38; EXPRESSION; CDNA; NAD+;
Keywords:
CYCLIC ADP-RIBOSE; OVOTESTIS; CD38; NUCLEOTIDE SEQUENCE; CLONING; EXON; INTRON; RECOMBINANT DNA;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
K. Nata et al., "THE STRUCTURE OF THE APLYSIA-KURODAI GENE ENCODING ADP-RIBOSYL CYCLASE, A 2ND-MESSENGER ENZYME", Gene, 158(2), 1995, pp. 213-218

Abstract

The complete nucleotide (nt) sequences of the cDNA and gene encoding the marine mollusk Aplysia kurodai (Ak) ADP-ribosyl cyclase (ADRC) which synthesizes cyclic ADP-ribose (cADP-ribose), a second messenger forCa2+ mobilization from endoplasmic reticulum, were determined. Ak ADRC consists of 258 amino acids (aa) (29 kDa). It shares 86% aa sequencehomology with that from A. californica, and 31-32% homology with the human, rat and mouse cluster of differentiation 38 (CD38) that has both ADRC and cADP-ribose hydrolase activities. The Ak ADRC-encoding gene(ADRC) spans approx. 7 kb and contains eight exons and seven introns. The transcription start point (tsp) determined by primer extension analysis and S1 mapping is 28 bp downstream from the TATA box. This geneis expressed specifically in the ovotestis, although the mammalian CD38-encoding gene is expressed in many kinds of tissues and cells. The 5'-flanking region contains several consensus sequences responsible for the germ-cell-specific expression of the mouse zona pellucida 3 (ZP3) and Drosophila melanogaster chorion genes. The existence of the consensus sequences located at nt -1649, -1161, -234 and -90 may account for the ovotestis-specific expression of the Ak ADRC gene.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:40:36