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Titolo:
SENSITIVITY OF THE CELL TRANSIT ANALYZER (CTA) TO ALTERATIONS OF RED-BLOOD-CELL DEFORMABILITY - ROLE OF CELL-SIZE PORE-SIZE RATIO AND SAMPLE PREPARATION
Autore:
BASKURT OK; FISHER TC; MEISELMAN HJ;
Indirizzi:
AKDENIZ UNIV,FAC MED ANTALYA TURKEY USC,SCH MED,DEPT PHYSIOL & BIOPHYS LOS ANGELES CA 00000
Titolo Testata:
Clinical hemorheology
fascicolo: 6, volume: 16, anno: 1996,
pagine: 753 - 765
SICI:
0271-5198(1996)16:6<753:SOTCTA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROCYTE DEFORMABILITY; INSTRUMENT; FLOW;
Keywords:
CELL TRANSIT ANALYZER; RED BLOOD CELL DEFORMABILITY; SENSITIVITY; GLUTARALDEHYDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
O.K. Baskurt et al., "SENSITIVITY OF THE CELL TRANSIT ANALYZER (CTA) TO ALTERATIONS OF RED-BLOOD-CELL DEFORMABILITY - ROLE OF CELL-SIZE PORE-SIZE RATIO AND SAMPLE PREPARATION", Clinical hemorheology, 16(6), 1996, pp. 753-765

Abstract

The sensitivity of the Cell Transit Analyzer (CTA) to the alterationsof red blood cell (RBC) deformability and related factors was investigated. Using 5 mu m pore size filters the CTA was found to be more sensitive to slight glutaraldehyde-induced decreases of deformability forrat RBC in comparison with larger human RBC. However, using 3 mu m pore size filters decreased the sensitivity of measurements to mechanical changes of rat RBC, implying that a lower cell/pore size ratio mightprovide better sensitivity. Exclusion of a subpopulation of the most rigid cells, which are not able to pass through the pores might be involved. Measurements using RBC suspensions with various cell counts revealed that RBC concentration in the suspension being filtered was an important determinant of CTA sensitivity, especially for measurements on human RBC using 5 mu m pore size filters. The insensitivity of CTA to slight changes in deformability might, in part, be related to the higher probability of longer pulses being rejected as a result of coincidence. Either decreasing the cell/pore size ratio or limiting the cellcount in the suspensions being filtered might optimize the sensitivity of the CTA to slight degrees of mechanical alterations in human RBC. Copyright (C) 1996 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:26:28