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Titolo:
EVALUATION OF RESPONSE TO RADIOTHERAPY IN DEAD-END NECK-CANCER BY POSITRON EMISSION TOMOGRAPHY AND [C-11] METHIONINE
Autore:
LINDHOLM P; LESKINENKALLIO S; GRENMAN R; LEHIKOINEN P; NAGREN K; TERAS M; RUOTSALAINEN U; JOENSUU H;
Indirizzi:
UNIV TURKU,CENT HOSP,DEPT RADIOTHERAPY & ONCOL SF-20520 TURKU FINLAND UNIV TURKU,DEPT RADIOTHERAPY & ONCOL SF-20520 TURKU FINLAND TURKU UNIV,CTR CYCLOTRON POSITRON EMISS TOMOG,RADIOPHARMACEUT CHEM LAB SF-20520 TURKU FINLAND UNIV TURKU,DEPT OTORHINOLARYNGOL SF-20520 TURKU FINLAND
Titolo Testata:
International journal of radiation oncology, biology, physics
fascicolo: 3, volume: 32, anno: 1995,
pagine: 787 - 794
SICI:
0360-3016(1995)32:3<787:EORTRI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-11 L-METHIONINE; RADIATION-THERAPY; SALIVARY FUNCTION; BREAST-CANCER; TUMOR UPTAKE; PET; L-)METHYL-C-11>METHIONINE; FLUORODEOXYGLUCOSE; CARBON-11-METHIONINE; HEAD;
Keywords:
POSITRON EMISSION TOMOGRAPHY; [C-11] METHIONINE; TREATMENT RESPONSE; RADIOTHERAPY; HEAD AND NECK CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
P. Lindholm et al., "EVALUATION OF RESPONSE TO RADIOTHERAPY IN DEAD-END NECK-CANCER BY POSITRON EMISSION TOMOGRAPHY AND [C-11] METHIONINE", International journal of radiation oncology, biology, physics, 32(3), 1995, pp. 787-794

Abstract

Purpose: To evaluate the usefulness of positron emission tomography (PET) and L-[methyl-C-11] methionine in assessing treatment response toradiotherapy in head and neck cancer. Methods and Materials: Fifteen patients with head and neck cancer (13 with squamous cell carcinoma, 1with adenocystic carcinoma, and 1 with paranasal plasmocytoma) underwent a PET study with [C-11]-methionine both before and after preoperative radiotherapy to the total tumor dose of 61-73 Gy. Twelve primary and 12 metastatic tumor sites were within the field of view. Nineteen of the 24 tumor sites were surgically explored after radiotherapy, and the tumor standardized uptake values (SUVs) of [C-11]methionine were compared with histological findings. Results: All 24 malignant lesions were detectable in the pretreatment study. In all but one case, the tumor SW decreased after radiotherapy. The median SUV of the tumor site was smaller (1.9, range, 1.3-3.1, n = 7) in cases with histologically verified complete response than in cases with persistent cancer (median 4.1, range, 2.8-7.6, n = 12, p = 0.0008). A complete histological response was verified in none of the 9 cases with a postirradiation SUV larger than the median (3.1), whereas 7 of the 10 cases with a SW of 3.1 or smaller had complete response (p = 0.003). The preirradiation uptake of [C-11]methionine in tumors did not have significant association with histological response (p = 0.45). The PET findings correlated well with follow-up data in five cases with unoperated tumor sites. The[C-11]methionine uptake of the submandibular salivary glands decreased after radiotherapy (p = 0.04). Conclusion: PET with [C-11]methionineas a tracer may be useful in assessing response to radiotherapy in head and neck cancer. High uptake of [C-11]methionine in the postirradiation scan suggests the presence of persistent disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 15:24:03