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Titolo:
EFFECTIVENESS OF ADJUNCTIVE TREATMENT WITH STEROIDS IN REDUCING SHORT-TERM MORTALITY IN A HIGH-RISK POPULATION OF CHILDREN WITH BACTERIAL-MENINGITIS
Autore:
CIANA G; PARMAR N; ANTONIO C; PIVETTA S; TAMBURLINI G; CUTTINI M;
Indirizzi:
IST INFANZIA,BUR INT HLTH,VIA ISTRIA 65-1 TRIESTE ITALY IST INFANZIA,BUR INT HLTH TRIESTE ITALY IST INFANZIA,DEPT PAEDIAT TRIESTE ITALY CENT HOSP,DEPT PAEDIAT MAPUTO MOZAMBIQUE IST INFANZIA,EPIDEMIOL UNIT TRIESTE ITALY
Titolo Testata:
Journal of tropical pediatrics
fascicolo: 3, volume: 41, anno: 1995,
pagine: 164 - 168
SICI:
0142-6338(1995)41:3<164:EOATWS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEXAMETHASONE THERAPY; HEMOPHILUS-INFLUENZAE; ANTIBIOTIC-RESISTANCE; CEFTRIAXONE; CHLORAMPHENICOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
G. Ciana et al., "EFFECTIVENESS OF ADJUNCTIVE TREATMENT WITH STEROIDS IN REDUCING SHORT-TERM MORTALITY IN A HIGH-RISK POPULATION OF CHILDREN WITH BACTERIAL-MENINGITIS", Journal of tropical pediatrics, 41(3), 1995, pp. 164-168

Abstract

Bacterial meningitis is still an important cause of death and/or persistent nervous system damage in children living in developing countries. The aim of the study was to evaluate the effectiveness of steroids in reducing mortality and neurologic sequelae in children affected by bacterial meningitis within the context of a developing country (Mozambique), where the case-fatality rate of this disease is over 30 per cent. Seventy children with bacterial meningitis were randomized to receive either conventional antibiotic therapy or antibiotic therapy plus dexamethasone. On hospital admission there were no statistically significant differences between the two groups with regard to clinical and laboratoristic features. When dexamethasone was used early mortality, within 24 h, was significantly reduced (1/34 v. 8/36, P < 0.05). Totalmortality among steroid treated patients, including those who were comatose on admission, was also reduced even if the difference did nor reach statistical significance. A favourable trend in terms of fewer serious neurologic abnormalities was also observed among survivors in the steroid treated patients (5/26 v. 7/24). Fever and CSF abnormalitiesalso disappeared more rapidly in patients receiving dexamethasone (P < 0.05). This study showed that the beneficial effect of adjunctive steroid therapy in children with bacterial meningitis can be even more important in areas where the case-fatality rate of this disease is still very high.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:05:07