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Titolo:
COMPLETE ASSIGNMENT OF THE H-1 AND C-13 NMR-SPECTRA AND SOLUTION CONFORMATION OF THE ANTITUMOR ANTIBIOTIC, ACLACINOMYCIN-A
Autore:
PARKINSON JA; SADLER IH; PICKUP MB; TABOR AB;
Indirizzi:
UNIV EDINBURGH,DEPT CHEM,W MAINS RD EDINBURGH EH9 3JJ MIDLOTHIAN SCOTLAND UNIV EDINBURGH,DEPT CHEM EDINBURGH EH9 3JJ MIDLOTHIAN SCOTLAND UNIV LONDON UNIV COLL,CHRISTOPHER INGOLD LABS,DEPT CHEM LONDON WC1H 0AJ ENGLAND
Titolo Testata:
Tetrahedron
fascicolo: 26, volume: 51, anno: 1995,
pagine: 7215 - 7222
SICI:
0040-4020(1995)51:26<7215:CAOTHA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA; PULSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Parkinson et al., "COMPLETE ASSIGNMENT OF THE H-1 AND C-13 NMR-SPECTRA AND SOLUTION CONFORMATION OF THE ANTITUMOR ANTIBIOTIC, ACLACINOMYCIN-A", Tetrahedron, 51(26), 1995, pp. 7215-7222

Abstract

As a prelude to the study of the molecular recognition of DNA by anthracycline antibiotics, and as a basis for comparison with synthetic analogues the proton and carbon-13 NMR spectra of Aclacinomycin A in chloroform have been fully assigned and the likely solution conformation determined using COSY, HMQC and 1-D TOCSY and 1-D ROESY techniques. The D-ring of the fused tetracyclic ring system adopts a half-chair conformation and the sugar residues are shown to lie essentially in chair conformations with the glycosidic links diaxial. This imposes considerable restriction in the rotation about the glycosidic links.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:46:29