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Titolo:
GENERATION OF NORMAL HUMAN RED-CELL VOLUME, HEMOGLOBIN CONTENT, AND MEMBRANE AREA DISTRIBUTIONS BY BIRTH OR REGULATION
Autore:
LEW VL; RAFTOS JE; SORETTE M; BOOKCHIN RM; MOHANDAS N;
Indirizzi:
UNIV CAMBRIDGE,PHYSIOL LAB,DOWNING ST CAMBRIDGE CB2 3EG ENGLAND MONASH UNIV,DEPT PHYSIOL CLAYTON VIC 3168 AUSTRALIA MILES INC TARRYTOWN NY 00000 ALBERT EINSTEIN COLL MED BRONX NY 10467 UNIV CALIF BERKELEY,LAWRENCE BERKELEY LAB,DIV LIFE SCI BERKELEY CA 94720
Titolo Testata:
Blood
fascicolo: 1, volume: 86, anno: 1995,
pagine: 334 - 341
SICI:
0006-4971(1995)86:1<334:GONHRV>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ION-CONTENT REGULATION; LIGHT-SCATTERING; ERYTHROCYTES; TRANSPORT; DENSITY; LEUKOCYTES; SEPARATION; ACCURATE; REMOVAL; ANEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
V.L. Lew et al., "GENERATION OF NORMAL HUMAN RED-CELL VOLUME, HEMOGLOBIN CONTENT, AND MEMBRANE AREA DISTRIBUTIONS BY BIRTH OR REGULATION", Blood, 86(1), 1995, pp. 334-341

Abstract

Using flow cytometry and osmotic lysis measurements, we document herethe means and coefficients of variation of the following red cell (RBC) properties: hemoglobin (Hb) content, volume, Hb concentration, and relative lytic tonicity distributions in populations of normal human RBCs, before and after density fractionation. The distributions showed a pattern characterized by much larger coefficients of variation of the Hb content and volume distributions than of the Hb concentration andrelative lytic tonicity distributions. From analysis of the factors that determine those RBC properties, the patterns were interpreted as reflecting previously unrecognized statistical proportionalities between cell osmolyte content, Hb content, and membrane area. The possible origin of these statistical links was analyzed by considering alternative models with and without the participation of regulatory processes during cell maturation. A model was shown to be feasible in which mature RBC variability with proportional volume, area, and Hb content arises solely from cell size variability at the last erythroid cell division. (C) 1995 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 22:06:54