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Titolo:
THE HYDROXYLATION OF OMEPRAZOLE CORRELATES WITH S-MEPHENYTOIN METABOLISM - A POPULATION STUDY
Autore:
BALIAN JD; SUKHOVA N; HARRIS JW; HEWETT J; PICKLE L; GOLDSTEIN JA; WOOSLEY RL; FLOCKHART DA;
Indirizzi:
GEORGETOWN UNIV,MED CTR,DEPT MED,DIV CLIN PHARMACOL,3900 RESERVOIR RDNW,ROOM GM12A WASHINGTON DC 20007 GEORGETOWN UNIV,MED CTR,DEPT MED,DIV CLIN PHARMACOL WASHINGTON DC 20007 GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL WASHINGTON DC 20007 US FDA,CTR DRUG EVALUAT & RES ROCKVILLE MD 20857 NATL CTR HLTH STAT HYATTSVILLE MD 20782 NIEHS RES TRIANGLE PK NC 27709
Titolo Testata:
Clinical pharmacology and therapeutics
fascicolo: 6, volume: 57, anno: 1995,
pagine: 662 - 669
SICI:
0009-9236(1995)57:6<662:THOOCW>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC-POLYMORPHISM; DRUG-METABOLISM; BLADDER-CANCER; OXIDATION; DEBRISOQUIN; CAUCASIANS; RATIO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Balian et al., "THE HYDROXYLATION OF OMEPRAZOLE CORRELATES WITH S-MEPHENYTOIN METABOLISM - A POPULATION STUDY", Clinical pharmacology and therapeutics, 57(6), 1995, pp. 662-669

Abstract

We compared omeprazole and mephenytoin as probes for the CYP2C19 metabolic polymorphism, Single oral doses of omeprazole (20 mg) or mephenytoin (100 mg) were administered at least 1 week apart to 167 healthy volunteers, Mephenytoin metabolism was measured using the amount of 4'-hydroxymephenytoin and the S/R ratio of mephenytoin in an 8-hour urinecollection, Omeprazole hydroxylation was measured using the ratio of omeprazole to 5'-hydroxyomeprazole in serum 2 hours after dosing, All three methods separated poor- or extensive-metabolizer phenotypes withcomplete concordance, Omeprazole hydroxylation correlated with the S/R ratio of mephenytoin in extensive metabolizers (r(2) = 0.681; P < 0.001), Genotyping tests showed that six poor metabolizers of omeprazolewere homozygous for a single base pair mutation in exon 5 of CYP2C19. These results support the hypothesis that omeprazole 5'-hydroxylationcosegregates with the CYP2C19 metabolic polymorphism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:27:27