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Titolo:
EFFECTS OF CHRONIC NO SYNTHASE INHIBITION IN RATS ON RENIN-ANGIOTENSIN SYSTEM AND SYMPATHETIC NERVOUS-SYSTEM
Autore:
ZANCHI A; SCHAAD NC; OSTERHELD MC; GROUZMANN E; NUSSBERGER J; BRUNNER HR; WAEBER B;
Indirizzi:
CHU VAUDOIS,DIV HYPERTENS CH-1011 LAUSANNE SWITZERLAND UNIV GENEVA,SCH MED,DIV CLIN PSYCHOPHARMACOL CH-1225 CHENE BOURG SWITZERLAND UNIV LAUSANNE HOSP,DIV PATHOL CH-1011 LAUSANNE SWITZERLAND UNIV LAUSANNE HOSP,DIV HYPERTENS CH-1011 LAUSANNE SWITZERLAND
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 6, volume: 37, anno: 1995,
pagine: 2267 - 2273
SICI:
0363-6135(1995)37:6<2267:EOCNSI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHESIS; L-ARGININE; RELAXING FACTOR; NEUROPEPTIDE-Y; SUSTAINED HYPERTENSION; ENDOTHELIAL-CELLS; BLOOD-PRESSURE; BLOCKADE; RELEASE; ENZYME;
Keywords:
N-G-NITRO-L-ARGININE-METHYL ESTER; CATECHOLAMINE, NEUROPEPTIDE Y; PLASMA RENIN ACTIVITY; SALT INTAKE; LOSARTAN; PHENTOLAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
A. Zanchi et al., "EFFECTS OF CHRONIC NO SYNTHASE INHIBITION IN RATS ON RENIN-ANGIOTENSIN SYSTEM AND SYMPATHETIC NERVOUS-SYSTEM", American journal of physiology. Heart and circulatory physiology, 37(6), 1995, pp. 2267-2273

Abstract

This study was designed to assess the role of renin and of the sympathoadrenal system in the maintenance of the hypertension induced by chronic nitric oxide synthase (NOS) inhibition in rats kept on a normal (RS) or a low-sodium (LS) diet. With the administration of N-G-nitro-L-arginine methyl ester (L-NAME) in drinking water (0.4 g/l) for 6 wk, mean intra-arterial blood pressure rose to a similar extent to 201 mmHgin the RS and 184 mmHg in the LS animals. Simultaneously, plasma norepinephrine was increased to 838 and 527 pg/ml and epinephrine to 2,041and 1,341 pg/ml in RS and LS, respectively. Plasma neuropeptide Y levels did not change. Plasma renin activity rose to 21 ng . ml(-1). h(-1) in RS but remained at 44 ng . ml(-1). h(-1) in the LS. Both losartan(10 mg/kg) and phentolamine (0.1 mg/kg) intravenous bolus injections reduced blood pressure considerably in the L-NAME hypertensive animals. Whole brain NOS activity was reduced by 84%. Hypertension induced bychronic NOS inhibition in LS as well as in RS fed rats seems to be sustained by an interaction of several mechanisms, including the activation of the sympathetic nervous system and the renin-angiotensin system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 12:58:20