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Titolo:
WELL-DIFFERENTIATED ENDOCRINE TUMORS OF THE MIDDLE-EAR AND OF THE HINDGUT HAVE IMMUNOCYTOCHEMICAL AND ULTRASTRUCTURAL FEATURES IN COMMON
Autore:
AZZONI C; BONATO M; DADDA T; USELLINI L; PIAZZA F; GANDOLFI A; BORDI C; CAPELLA C;
Indirizzi:
UNIV PARMA,INST PATHOL ANAT I-43100 PARMA ITALY UNIV PARMA,INST PATHOL ANAT I-43100 PARMA ITALY UNIV PARMA,EAR NOSE & THROAT CLIN 2 I-43100 PARMA ITALY UNIV PAVIA,VARESE & MULTIZONAL HOSP,DEPT HUMAN PATHOL VARESE ITALY
Titolo Testata:
Virchows Archiv
fascicolo: 4, volume: 426, anno: 1995,
pagine: 411 - 418
SICI:
0945-6317(1995)426:4<411:WETOTM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOID-TUMOR; CELLS; IMMUNOREACTIVITIES; GLICENTIN; GLUCAGON; MUCOSA;
Keywords:
MIDDLE EAR; WELL-DIFFERENTIATED ENDOCRINE TUMOR; CARCINOID TUMOR; PANCREATIC POLYPEPTIDE-RELATED PEPTIDES; GLUCAGON-RELATED PEPTIDES; SEROTONIN;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C. Azzoni et al., "WELL-DIFFERENTIATED ENDOCRINE TUMORS OF THE MIDDLE-EAR AND OF THE HINDGUT HAVE IMMUNOCYTOCHEMICAL AND ULTRASTRUCTURAL FEATURES IN COMMON", Virchows Archiv, 426(4), 1995, pp. 411-418

Abstract

The immunocytochemical analysis of two cases of well-differentiated endocrine tumours (carcinoids) of the middle ear revealed predominant cell populations producing pancreatic polypeptide (PP)-related peptides, glucagon-related peptides, and serotonin (the latter only in one case). In consecutive sections PP- and glucagon-related immunoreactivities mainly colocalized in the same tumour cells. Ultrastructurally tumour cells were characterized by medium-sized to large granules of moderate to high density, on which PP and glicentin were localized by the immunogold technique. No amphicrine cells were found. These features areconsistent with those of similar tumours in the rectal mucosa that are mainly composed of L cells coexpressing both PP-related and glucagon-related peptides. Additional tumour antigens of hindgut type detectedimmunohistochemically were prostatic acid phosphatase and CAR-5 mucin. Expression of the CAR-5 antigen was also found in samples of normal middle ear mucosa, in which endocrine cells have not been identified. In case 1 peritumoral mucosal invaginations showed a proliferation of endocrine cells identical immunophenotypically to tumour cells, possibly representing a precursor lesion. It is concluded that well-differentiated endocrine tumours of the middle ear are a distinct pathologicalentity characterized by multiple hormone production, typically involving three classes of hormones (pancreatic polypeptide-related peptides, glucagon-related peptides, and serotonin) of the hindgut endocrine system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:25:04