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Titolo:
LEUKEMOGENIC PROGRESSION - THE IMPORTANCE OF DIFFERENTIATION AND ASSOCIATED GENETIC EVENTS
Autore:
HO ESP; ONEILL HC;
Indirizzi:
AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DIV CLIN SCI,MOLEC IMMUNOL LAB CANBERRA ACT 2601 AUSTRALIA AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DIV CLIN SCI,MOLEC IMMUNOL LAB CANBERRA ACT 2601 AUSTRALIA
Titolo Testata:
Immunology and cell biology
fascicolo: 3, volume: 73, anno: 1995,
pagine: 193 - 197
SICI:
0818-9641(1995)73:3<193:LP-TIO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE LEUKEMIA-VIRUS; T-CELL LYMPHOMAGENESIS; MYELOGENOUS LEUKEMIA; AKR MICE; LINEAGE INFIDELITY; TARGET-CELLS; GROWTH; INTEGRATION; THYMOMAS; DNA;
Keywords:
DIFFERENTIATION; LEUKEMIA; ONCOGENESIS; RETROVIRUS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
E.S.P. Ho e H.C. Oneill, "LEUKEMOGENIC PROGRESSION - THE IMPORTANCE OF DIFFERENTIATION AND ASSOCIATED GENETIC EVENTS", Immunology and cell biology, 73(3), 1995, pp. 193-197

Abstract

A feature common to many blood cell cancers is the uncoupling of normal proliferative and differentiative events, both of which are intimately linked in the cell's developmental programme. In some cancers, further differentiative events have been associated with oncogenic progression and; in other cancers, terminal differentiation of cells has been shown to result in reversal of malignancy and death of the cancer cell. Clearly the development of cancer is not the result of a single oncogenic event, but rather a myriad of events which appear to proceed in concert in a step-wise fashion and which are likely to be influencedby-the cellular environment. Here we review some of the major geneticchanges which occur in leukaemogenesis and discuss the possible role of differentiative events in the development of leukaemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:56:40