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Titolo:
GENETIC-ANALYSIS OF THE CYP2D LOCUS IN RELATION TO DEBRISOQUINE HYDROXYLATION CAPACITY IN KOREAN, JAPANESE AND CHINESE SUBJECTS
Autore:
DAHL ML; YUE QY; ROH HK; JOHANSSON I; SAWE J; SJOQVIST F; BERTILSSON L;
Indirizzi:
HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT MED LAB SCI & TECHNOL,DIV CLIN PHARMACOL S-14186 HUDDINGE SWEDEN KAROLINSKA INST,DEPT MED BIOCHEM & BIOPHYS S-17177 STOCKHOLM SWEDEN
Titolo Testata:
Pharmacogenetics
fascicolo: 3, volume: 5, anno: 1995,
pagine: 159 - 164
SICI:
0960-314X(1995)5:3<159:GOTCLI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEPHENYTOIN HYDROXYLATION; S-MEPHENYTOIN; INTERETHNIC DIFFERENCES; SWEDISH POPULATION; GAS-CHROMATOGRAPHY; POOR METABOLIZERS; NATIVE CHINESE; POLYMORPHISM; OXIDATION; SPARTEINE;
Keywords:
DEBRISOQUINE; MEPHENYTOIN; DRUG METABOLISM; INTERETHNIC DIFFERENCES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Dahl et al., "GENETIC-ANALYSIS OF THE CYP2D LOCUS IN RELATION TO DEBRISOQUINE HYDROXYLATION CAPACITY IN KOREAN, JAPANESE AND CHINESE SUBJECTS", Pharmacogenetics, 5(3), 1995, pp. 159-164

Abstract

The CYP2D6 genotype and the debrisoquine and mephenytoin hydroxylation phenotypes were studied in 63 Oriental subjects including 21 Chinese, 21 Japanese and 21 Koreans, All subjects were extensive metabolizersof debrisoquine, The incidence of the S-mephenytoin poor metabolizer phenotype was 14% in the Chinese, 24% in the Japanese and 24% in the Korean population, respectively, which is similar to previous reports, The CYP2D6 genotype was analysed by Xba I and Eco RI RFLP, and by allele-specific PCR analysis for the presence of several allelic variants of the CYP2D locus, No CYP2D6A or CYP2D6B alleles, two of the most common defect alleles among Caucasians, were found among the Oriental subjects, The frequency of the CYP2D6D allele was similar to that in Caucasian populations and consistent with the low incidence of the poor metabolizer phenotype in all three Oriental populations, The CYP2D6L(2)-allele with duplication of an active CYP2D6L gene was identified in one Korean and one Chinese allele in association with high CYP2D6 activity, The CYP2D6Ch alleles CYP2D6Ch(1) and Ch(2), identified by RFLP andPCR for the -1338C --> T and 188C --> T mutations, were the most frequent allelic variants in all three populations studied, and were related to a decreased CYP2D6 activity as previously shown in Chinese, In conclusion, the present pilot study revealed major similarities in the polymorphic CYP2D locus between Korean, Japanese and Chinese populations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:38:17