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Titolo:
SERUM PROLACTIN LEVELS AND THEIR RELATIONSHIP TO SURVIVAL IN WOMEN WITH OPERABLE BREAST-CANCER
Autore:
WANG DY; STEPNIEWSKA KA; ALLEN DS; FENTIMAN IS; BULBROOK RD; KWA HG; DESTAVOLA BL; REED MJ;
Indirizzi:
UNIV LONDON LONDON SCH HYG & TROP MED,DEPT EPIDEMIOL & POPULAT SCI,KEPPEL ST LONDON WC1E 7HT ENGLAND ST MARYS HOSP,SCH MED,METAB MED UNIT LONDON W2 1PG ENGLAND IMPERIAL CANC RES FUND,MED STAT LAB LONDON WC2A 3PX ENGLAND IMPERIAL CANC RES FUND,DEPT MATH STAT & EPIDEMIOL LONDON WC2A 3PX ENGLAND IMPERIAL CANC RES FUND,CLIN ONCOL UNIT LONDON WC2A 3PX ENGLAND IMPERIAL CANC RES FUND,CLIN ENDOCRINOL LAB LONDON WC2A 3PX ENGLAND NETHERLANDS CANC INST 1066 CX AMSTERDAM NETHERLANDS
Titolo Testata:
Journal of clinical epidemiology
fascicolo: 7, volume: 48, anno: 1995,
pagine: 959 - 968
SICI:
0895-4356(1995)48:7<959:SPLATR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC-SIGNIFICANCE; PLASMA PROLACTIN; DISEASE; HYPERPROLACTINEMIA; PROGRESSION; INDICATOR; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
D.Y. Wang et al., "SERUM PROLACTIN LEVELS AND THEIR RELATIONSHIP TO SURVIVAL IN WOMEN WITH OPERABLE BREAST-CANCER", Journal of clinical epidemiology, 48(7), 1995, pp. 959-968

Abstract

The prognostic value of serum prolactin levels was assessed in a sequential series of 739 patients who were initially treated at Guy's Hospital, London, between 1975 and 1980. Prolactin was measured in 472 patients 1 day before (Hpr1) and in 457 patients 10 days after (Hpr2) mastectomy. Follow-up of the patients was up to August 1992 giving 6139 women-years with a median follow-up time of 11.5 years (13.7 for patients still living and 5.1 for those dead). The association between the three prolactin variables and reproductive and clinical factors was examined before assessing the prognostic value of prolactin levels in terms of overall, disease-specific and disease-free survival. Multivariate survival models were used in order to adjust for the effect of otherprognostic variables. These were found to be: tumour size, degree of nodal involvement, tumour grade and age at diagnosis. The results showed that high Hpr2 or high postoperative increase in prolactin (i.e. Hpr2 -Hpr1) were significantly related to shorter disease-specific survival (p = 0.04 and 0.01, respectively) in postmenopausal women. In addition there was some indication, which did not attain formal significance, for this association to occur for disease-free survival. Thus the rise in blood prolactin levels after surgery may be a weak indicator of poor prognosis of breast cancer in postmenopausal women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 01:06:15