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Titolo:
MODEL OF RESPIRATORY SENSATION AND WILLFUL CONTROL OF VENTILATION
Autore:
OKU Y; SAIDEL GM; CHERNIACK NS; ALTOSE MD;
Indirizzi:
KYOTO UNIV,CHEST DIS RES INST,DEPT CLIN PHYSIOL KYOTO 606 JAPAN CASE WESTERN RESERVE UNIV,DEPT MED CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT BIOCHEM ENGN CLEVELAND OH 44106 VET ADM MED CTR CLEVELAND OH 44106
Titolo Testata:
Medical & biological engineering & computing
fascicolo: 3, volume: 33, anno: 1995,
pagine: 252 - 256
SICI:
0140-0118(1995)33:3<252:MORSAW>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREATHLESSNESS; DYSPNEA; HYPERCAPNIA; EXERCISE; HUMANS; CORTEX; CO2;
Keywords:
DYSPNEA; MODEL; WILLFUL CONTROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
Y. Oku et al., "MODEL OF RESPIRATORY SENSATION AND WILLFUL CONTROL OF VENTILATION", Medical & biological engineering & computing, 33(3), 1995, pp. 252-256

Abstract

A mathematical model has been developed that includes sensations of breathlessness and a dynamic CO2 respiratory controller. Breathing sensations, which are represented as a discomfort index, are assumed to depend on arterial PCO2 level, automatic and wilful motor commands and mechanoreceptor feedback. Wilful control is assumed to arise from cortical centres of the brain and is independent of the reflex control system. The bulbopontine respiratory controller produces the automatic motor command, which is determined by chemical and mechanical feedback. Simulations demonstrate how the controller output and breathing sensations change when wilful motor commands disturb spontaneous breathing. Simulations include isocapnic hyper- and hypoventilation and deliberatehypoventilation during CO2 rebreathing. Simulations are compared withexperimental data from human subjects. Simulations predict that the discomfort index intensifies when ventilation is either voluntarily raised or lowered from the optimal level; and discomfort is greater when ventilation is lowered than when it is raised at a given level of PCO2. The simulated results agree with those obtained experimentally. The simulations suggest that respiratory drive Integration may depend not only on the direct effects of chemical and mechanical feedback, but also on the perceptual consequences of these stimuli.

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Documento generato il 27/01/20 alle ore 01:23:05