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Titolo:
NEUROPSYCHOLOGICAL TESTS AND [TC-99M]-HM PAO SPECT IN THE DIAGNOSIS OF ALZHEIMERS DEMENTIA
Autore:
VILLA G; CAPPA A; TAVOLOZZA M; GAINOTTI G; GIORDANO A; CALCAGNI ML; DEROSSI G;
Indirizzi:
CATHOLIC UNIV SACRED HEART,POLICLIN A GEMELLI,IST NEUROL,LARGO A GEMELLI 8 I-00168 ROME ITALY CATHOLIC UNIV SACRED HEART,POLICLIN A GEMELLI,IST MED NUCL I-00168 ROME ITALY
Titolo Testata:
Journal of neurology
fascicolo: 6, volume: 242, anno: 1995,
pagine: 359 - 366
SICI:
0340-5354(1995)242:6<359:NTA[PS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; EMISSION COMPUTED-TOMOGRAPHY; ADRDA WORK GROUP; TC-99M HM-PAO; COGNITIVE PERFORMANCE; CLINICAL-DIAGNOSIS; DISEASE; ATROPHY; PERFUSION; SEVERITY;
Keywords:
ALZHEIMERS DEMENTIA; NEUROPSYCHOLOGICAL TESTS; [TC-99M]-HM PAO; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
G. Villa et al., "NEUROPSYCHOLOGICAL TESTS AND [TC-99M]-HM PAO SPECT IN THE DIAGNOSIS OF ALZHEIMERS DEMENTIA", Journal of neurology, 242(6), 1995, pp. 359-366

Abstract

Twenty-three patients with Alzheimer's dementia (AD) in relatively early stages and 40 patients with other cognitive disorders of vascular or degenerative aetiology underwent neuropsychological examination and[Tc-99m]-HM PAO single photon emission computed tomography (SPECT). In contrast to the commonly accepted notion of a posterior temporoparietal reduction of tracer uptake as the typical SPECT pattern of AD, themost consistent feature found in the SPECT images of our AD patients was a hippocampal uptake deficit, associated with a variable degree oftemporal, parietal and frontal deficit (extending from the posterior to the anterior regions), according to the severity of the disease. These results support the theory of AD as a ''hippocampal dementia'', atleast in the early stages. Neuropsychological tests were found to be somewhat more specific and more accurate than SPECT in distinguishing AD from non-AD cases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:16:18