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Titolo:
ENDOTHELIN-3-INDUCED RELAXATION OF ISOLATED RAT BASILAR ARTERY IS MEDIATED BY AN ENDOTHELIAL ET(B)-TYPE ENDOTHELIN RECEPTOR
Autore:
SCHILLING L; FEGER GI; EHRENREICH H; WAHL M;
Indirizzi:
UNIV MUNICH,DEPT PHYSIOL,PETTENKOFERSTR 12 D-80336 MUNICH GERMANY UNIV MUNICH,DEPT PHYSIOL D-80336 MUNICH GERMANY UNIV GOTTINGEN,DEPT PSYCHIAT W-3400 GOTTINGEN GERMANY UNIV GOTTINGEN,DEPT NEUROL W-3400 GOTTINGEN GERMANY
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 4, volume: 15, anno: 1995,
pagine: 699 - 705
SICI:
0271-678X(1995)15:4<699:EROIRB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; RELAXING FACTOR; CEREBRAL-ARTERIES; ETA-RECEPTOR; GUINEA-PIG; ANTAGONIST; POTENT; CONTRACTION; IRL-1038; IRL-1620;
Keywords:
BASILAR ARTERY; ENDOTHELIN; ENDOTHELIUM-DEPENDENT RELAXATION; ET(B) RECEPTOR; IN VITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
L. Schilling et al., "ENDOTHELIN-3-INDUCED RELAXATION OF ISOLATED RAT BASILAR ARTERY IS MEDIATED BY AN ENDOTHELIAL ET(B)-TYPE ENDOTHELIN RECEPTOR", Journal of cerebral blood flow and metabolism, 15(4), 1995, pp. 699-705

Abstract

The endothelin (ET) receptor mediating relaxation of cerebral arteries was characterized using ring segments obtained from the rat basilar artery. Under resting tension, ET-3 (>10(-8) M) but not the specific ET(B) receptor agonist IRL 1620 induced contraction. In ring segments precontracted with 3 x 10(-6) M prostaglandin (PG) F-2 alpha, ET-3 (10(-12)-10(-8) M) and IRL 1620 (10(-14)-10(-6) M) induced concentration-related relaxation. IRL 1620 was more potent than ET-3, the pD(2) (-log(10)EC(50)) values being 10.002 +/- 0.751 (mean +/- SD) for IRL 1620 and 8.836 +/- 0.415 for ET-3. Relaxation was abolished after preincubation with the nitric oxide (NO) synthase inhibitor N-G-nitro-L-arginine(10(-5) M) as well as in segments devoid of a functionally intact endothelium. At a concentration above 10(-8) M, ET-3 resulted in a further increase of PGF(2 alpha)-induced contraction that was not observed with IRL 1620. The presumably specific ET(B) receptor antagonist IRL 1038 (10(-7)-3 x 10(-6) M) diminished or even abolished (3 x 10(-6) M) the relaxation induced by ET-3 or IRL 1620. IRL 1038 did not exert any vasomotor effect by itself, and it did not significantly affect ET3-induced contraction. These results indicate that in the rat isolated basilar artery, the ET3-induced relaxation is probably due to activation of an ET(B)-type receptor located on the endothelial cells and mediated by release of nitric oxide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:37:17