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Titolo: INTERVAL MAPPING OF QUANTITATIVE TRAIT LOCI EMPLOYING CORRELATED TRAIT COMPLEXES
Autore: KOROL AB; RONIN YI; KIRZHNER VM;
 Indirizzi:
 UNIV HAIFA,INST EVOLUT IL31905 HAIFA ISRAEL
 Titolo Testata:
 Genetics
fascicolo: 3,
volume: 140,
anno: 1995,
pagine: 1137  1147
 SICI:
 00166731(1995)140:3<1137:IMOQTL>2.0.ZU;2B
 Fonte:
 ISI
 Lingua:
 ENG
 Soggetto:
 MARKER LOCI; DETERMINING LINKAGE; POWER; POPULATIONS; EFFICIENCY; BACKCROSS; CROSSES; DESIGNS; MAIZE;
 Tipo documento:
 Article
 Natura:
 Periodico
 Settore Disciplinare:
 Science Citation Index Expanded
 Citazioni:
 33
 Recensione:
 Indirizzi per estratti:



 Citazione:
 A.B. Korol et al., "INTERVAL MAPPING OF QUANTITATIVE TRAIT LOCI EMPLOYING CORRELATED TRAIT COMPLEXES", Genetics, 140(3), 1995, pp. 11371147
Abstract
An approach to increase the resolution power of interval mapping of quantitative trait (QT) loci is proposed, based on analysis of correlated trait complexes. For a given set of QTs, the broad sense heritability attributed to a QT locus (QTL) (say, A/a) is an increasing functionof the number of traits. Thus, for some traits x and y, Hxy(2) (A/a)greater than or equal to Hx(2) (A/a). The last inequality holds evenif y does not depend on A/a at all, but x and y are correlated withinthe groups AA, Aa and aa due to nongenetic factors and segregation ofgenes from other chromosomes. A simple relationship connects H2 (both in single trait and twotrait analysis) with the expected LOD value,ELOD = 1/2 N log (1  H2). Thus, situations could exist that from the inequality Hxy(2) (A/a) greater than or equal to Hx(2) (A/a) a higher resolution is provided by the twotrait analysis as compared to the singletrait analysis, in spite of the increased number of parameters. Employing LODscore procedure to simulated backcross data, we showed that the resolution power of the QTL mapping model can be elevated if correlation between QTs is taken into account. The method allows usto test numerous biologically important hypotheses concerning manifold effects of genomic segments on the defined trait complex (means, variances and correlations).
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 06:44:21