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Titolo:
INTERVAL MAPPING OF QUANTITATIVE TRAIT LOCI EMPLOYING CORRELATED TRAIT COMPLEXES
Autore:
KOROL AB; RONIN YI; KIRZHNER VM;
Indirizzi:
UNIV HAIFA,INST EVOLUT IL-31905 HAIFA ISRAEL
Titolo Testata:
Genetics
fascicolo: 3, volume: 140, anno: 1995,
pagine: 1137 - 1147
SICI:
0016-6731(1995)140:3<1137:IMOQTL>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MARKER LOCI; DETERMINING LINKAGE; POWER; POPULATIONS; EFFICIENCY; BACKCROSS; CROSSES; DESIGNS; MAIZE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A.B. Korol et al., "INTERVAL MAPPING OF QUANTITATIVE TRAIT LOCI EMPLOYING CORRELATED TRAIT COMPLEXES", Genetics, 140(3), 1995, pp. 1137-1147

Abstract

An approach to increase the resolution power of interval mapping of quantitative trait (QT) loci is proposed, based on analysis of correlated trait complexes. For a given set of QTs, the broad sense heritability attributed to a QT locus (QTL) (say, A/a) is an increasing functionof the number of traits. Thus, for some traits x and y, H-xy(2) (A/a)greater than or equal to H-x(2) (A/a). The last inequality holds evenif y does not depend on A/a at all, but x and y are correlated withinthe groups AA, Aa and aa due to nongenetic factors and segregation ofgenes from other chromosomes. A simple relationship connects H-2 (both in single trait and two-trait analysis) with the expected LOD value,ELOD = -1/2 N log (1 - H-2). Thus, situations could exist that from the inequality H-xy(2) (A/a) greater than or equal to H-x(2) (A/a) a higher resolution is provided by the two-trait analysis as compared to the single-trait analysis, in spite of the increased number of parameters. Employing LOD-score procedure to simulated backcross data, we showed that the resolution power of the QTL mapping model can be elevated if correlation between QTs is taken into account. The method allows usto test numerous biologically important hypotheses concerning manifold effects of genomic segments on the defined trait complex (means, variances and correlations).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 06:44:21