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Titolo:
HIV-1 INFECTION OF PRIMARY HUMAN NEUROBLASTS
Autore:
ENSOLI F; CAFARO A; FIORELLI V; VANNELLI B; ENSOLI B; THIELE CJ;
Indirizzi:
NCI,PEDIAT BRANCH,CELL & MOLEC BIOL SECT,BLDG 10 BETHESDA MD 20892 NCI,TUMOR CELL BIOL LAB BETHESDA MD 20892 UNIV FLORENCE,DEPT ANAT & HISTOL FLORENCE ITALY
Titolo Testata:
Virology
fascicolo: 1, volume: 210, anno: 1995,
pagine: 221 - 225
SICI:
0042-6822(1995)210:1<221:HIOPHN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; IMMUNE-DEFICIENCY SYNDROME; CENTRAL-NERVOUS-SYSTEM; NEURONAL CELL-LINE; HUMAN GLIAL-CELLS; HTLV-III; PROGRESSIVE ENCEPHALOPATHY; PRODUCTIVE INFECTION; NEURAL CELLS; AIDS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
F. Ensoli et al., "HIV-1 INFECTION OF PRIMARY HUMAN NEUROBLASTS", Virology, 210(1), 1995, pp. 221-225

Abstract

Central nervous system (CNS) disorders are frequent in HIV-1-infectedindividuals, particularly in newborns and children, and are accompanied by histological alterations resulting in neuronal loss. Although several tumor-derived neuroectodermal cell lines can be infected by HIV-I, it has been reported that primary neural cells cannot be infected after they differentiate. However, pediatric AIDS is often the result of HIV-1 infection occurring during fetal development and early postnatal life, when neural cells are not yet differentiated. Here we show that primary cell cultures derived from the human fetal olfactory systemwhich are representative of the developing CNS can be infected by both HIV-1 strains, the monocyte-macrophagotropic Bat and the lymphotropic HTLV-IIIB, although they do not express the CD4 molecule. In addition, the levels of viral replication are higher with the HIV-1 Bat than with the IIIB isolate. These results suggest that (1) during development immature neurons are susceptible to HIV-1 infection; (2) monocyte-macrophagotropic HIV-1 strains may preferentially be involved in the productive infection of the nervous system; and (3) a mechanism(s) otherthan the CD4-mediated viral entry is responsible for HIV-1 infection of immature neurons. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 16:49:48