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Titolo:
EXPRESSION OF B7-1 BY HIGHLY METASTATIC MOUSE T-LYMPHOMAS INDUCES OPTIMAL NATURAL-KILLER CELL-MEDIATED CYTOTOXICITY
Autore:
GELDHOF AB; RAES G; BAKKUS M; DEVOS S; THIELEMANS K; DEBAETSELIER P;
Indirizzi:
FREE UNIV BRUSSELS,FLEMISH INST BIOTECHNOL,CELLULAR IMMUNOL LAB,IMOL 2,PAARDENSTR 65 B-1640 RHODE ST GENESE BELGIUM FREE UNIV BRUSSELS,SCH MED,PHYSIOL LAB B-1090 JETTE BELGIUM
Titolo Testata:
Cancer research
fascicolo: 13, volume: 55, anno: 1995,
pagine: 2730 - 2733
SICI:
0008-5472(1995)55:13<2730:EOBBHM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
COSTIMULATION; MOLECULES; IMMUNITY; CTLA-4; CD28;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
A.B. Geldhof et al., "EXPRESSION OF B7-1 BY HIGHLY METASTATIC MOUSE T-LYMPHOMAS INDUCES OPTIMAL NATURAL-KILLER CELL-MEDIATED CYTOTOXICITY", Cancer research, 55(13), 1995, pp. 2730-2733

Abstract

The interaction between B7-1 and CD28 provides costimulatory signals not only for T cells but also for natural killer (NK) cells, Highly metastatic mouse T lymphoma cells (BW-Li) can escape from MK cell-mediated killing by expressing H-2D(k) molecules that negatively regulate NKlytic activity, We have analyzed whether B7-1:CD28 overrules the MHC class I-mediated inactivation of NK cells by transfecting BW-Li with the gene coding for B7-1, Expression of B7-1 rendered BW-Li cells sensitive toward NK cells, The experimental metastatic capacity of the B7-1transfectants was drastically reduced in both syngeneic AKR and SCID mice but could be restored in SCID bg mice, These results provide direct evidence that B7-1 expression leads to NK-mediated elimination of metastasizing, NK-resistant tumor cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:14:19