Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE CLINICAL-VALUE OF TISSUE FACTOR ASSAYS
Autore:
FRANCIS JL; CARVALHO M; FRANCIS DA;
Indirizzi:
FLORIDA HOSP,WALT DISNEY MEM CANC INST,HEMOSTASIS & THROMBOSIS RES UNIT,616 E ALTAMONTE DR ALTAMONTE SPRINGS FL 32701
Titolo Testata:
Blood coagulation & fibrinolysis
, volume: 6, anno: 1995, supplemento:, 1
pagine: 37 - 44
SICI:
0957-5235(1995)6:<37:TCOTFA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCYTE PROCOAGULANT ACTIVITY; BLOOD-COAGULATION; ENDOTHELIAL-CELLS; ACTIVATION; CANCER; EXPRESSION; GENERATION; THROMBOPLASTIN; ABNORMALITIES; HEMOSTASIS;
Keywords:
TISSUE FACTOR; MONOCYTES; THROMBOPLASTIN; COAGULATION ACTIVATION; ASSAY METHODS; THROMBOSIS; DISSEMINATED INTRAVASCULAR COAGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Francis et al., "THE CLINICAL-VALUE OF TISSUE FACTOR ASSAYS", Blood coagulation & fibrinolysis, 6, 1995, pp. 37-44

Abstract

Tissue factor (TF) is now considered to be the primary physiologic activator of the blood coagulation system. Coupled with recent advances in our understanding of the biochemistry of TF this has heightened interest in measuring aspects of TF activity in disease states. Expression of TF by blood monocytes in various diseases is an established trigger for intravascular coagulation and there is now a considerable body of experience with its measurement. This has considerable clinical potential although more widespread application awaits a consensus on the most appropriate methodologic approach to its measurement. TF can be detected in urine and may reflect the activation state of renal macrophages. Urinary TF is increased in cancer and could have diagnostic and prognostic value in a variety of malignant diseases. Finally, it is now possible to measure soluble TF in plasma. One such assay is commercially available and is technically simple to perform. The clinical value of such assays, however, must await better understanding of the source and function of soluble TF in plasma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:18:37