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Titolo:
VITAMIN-K INTAKE AND OSTEOCALCIN LEVELS IN WOMEN WITH AND WITHOUT AORTIC ATHEROSCLEROSIS - A POPULATION-BASED STUDY
Autore:
JIE KSG; BOTS ML; VERMEER C; WITTEMAN JCM; GROBBEE DE;
Indirizzi:
UNIV LIMBURG,DEPT BIOCHEM,POB 616 6200 MD MAASTRICHT NETHERLANDS UNIV LIMBURG,DEPT BIOCHEM 6200 MD MAASTRICHT NETHERLANDS UNIV LIMBURG,CARDIOVASC RES INST 6200 MD MAASTRICHT NETHERLANDS ERASMUS UNIV ROTTERDAM,SCH MED,DEPT EPIDEMIOL & BIOSTAT ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,SCH MED,CARDIOVASC RES INST ROTTERDAM ROTTERDAM NETHERLANDS
Titolo Testata:
Atherosclerosis
fascicolo: 1, volume: 116, anno: 1995,
pagine: 117 - 123
SICI:
0021-9150(1995)116:1<117:VIAOLI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-CARBOXYGLUTAMIC ACID; URINARY CALCIUM EXCRETION; CONTAINING PROTEINS; BINDING PROTEINS; CALCIFICATION; GLA; PLAQUE; BONE; DEFICIENCY; DISEASE;
Keywords:
VITAMIN-K; GAMMA-CARBOXYGLUTAMATE; OSTEOCALCIN; CALCIFICATION; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
K.S.G. Jie et al., "VITAMIN-K INTAKE AND OSTEOCALCIN LEVELS IN WOMEN WITH AND WITHOUT AORTIC ATHEROSCLEROSIS - A POPULATION-BASED STUDY", Atherosclerosis, 116(1), 1995, pp. 117-123

Abstract

Protein-bound gamma-carboxyglutamate (Gla) has been demonstrated in calcified atherosclerotic plaques. Vitamin K is required for the formation of Cia-residues. As the biological activity of Cia-proteins appears to be strictly dependent on the presence of the Cia-residues, vitamin K status may be an important factor in the development and progression of atherosclerotic calcifications. We studied the association of vitamin K status, as assessed by nutritional vitamin K intake and the measurements of two circulating immunoreactive osteocalcin (irOC) fractions, with aortic atherosclerosis in a population-based study of 113 postmenopausal women. Women with calcified lesions (n = 34) had a 42.9 mu g lower mean age-adjusted dietary vitamin K intake/day (95% C.I. -6.6 to 92.5) than those without calcifications (n = 79). Atheroscleroticwomen had higher irOC levels with a low affinity for hydroxyapatite (irOC(free)): age-adjusted difference of 0.32 ng/ml (95% C.I. 0.03 to 0.61). In addition, the high affinity irOC levels expressed as a percentage (hydroxyapatite binding capacity, HBC) were 5.12% (95% C.I. 1.32 to 8.92) lower in women with calcifications. Our study indicates that women with aortic atherosclerosis have an impaired vitamin K status asreflected by a lower nutritional vitamin K intake, an increased irOC(free) level and a reduced HBC level. An impaired vitamin K status in subjects with atherosclerosis is compatible with the view that vitamin K or Gla-containing proteins are involved in the development of calcification of the vessel wall.

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Documento generato il 01/12/20 alle ore 09:28:23