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Titolo:
SELF-TOLERANCE TO T-CELL RECEPTOR V-BETA SEQUENCES
Autore:
FALCIONI F; VIDOVIC D; WARD ES; BOLIN D; SINGH G; SHAH H; OBER B; NAGY ZA;
Indirizzi:
HOFFMANN LA ROCHE INC,DEPT INFLAMMAT AUTOIMMUNE DIS,BLDG 86,ROOM 530,340 KINGSLAND ST NUTLEY NJ 07110 HOFFMANN LA ROCHE INC,DEPT INFLAMMAT AUTOIMMUNE DIS NUTLEY NJ 07110 UNIV TEXAS,SW MED CTR,CTR CANC IMMUNOBIOL,DEPT MICROBIOL DALLAS TX 75235
Titolo Testata:
The Journal of experimental medicine
fascicolo: 1, volume: 182, anno: 1995,
pagine: 249 - 254
SICI:
0022-1007(1995)182:1<249:STTRVS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; ESCHERICHIA-COLI; VARIABLE REGION; PEPTIDES; IMMUNIZATION; VACCINATION; REPERTOIRE; RESPONSES; SECRETION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
F. Falcioni et al., "SELF-TOLERANCE TO T-CELL RECEPTOR V-BETA SEQUENCES", The Journal of experimental medicine, 182(1), 1995, pp. 249-254

Abstract

T cell tolerance to self is achieved by deletion or inactivation of clones recognizing peptides of self proteins presented by major histocompatibility complex molecules. A considerable fraction of self proteins accessible to the immune system is contributed by the system itself,for example, the receptors used for antigen recognition (antibodies and T cell receptors [TCRs]). Thus far, it has remained unclear, whether antigen receptors are subject to self tolerance, or on contrary, engage into network interactions implying immunity rather than tolerance. In this study, we demonstrate self tolerance to synthetic peptides corresponding to the first hypervariable region of the V beta 8.1 and V beta 8.2 TCR proteins. We also show that the tolerogenic synthetic peptide corresponds to a fragment produced by processing of the V beta protein, and conversely, that a V beta peptide not produced by processing is also not subject to self tolerance. Thus, the rules of tolerance seem to apply to antigen receptors, at least to their germline-encodedportions, in a similar fashion as to other self proteins. This finding has important implications for studies of natural and artificially induced immune networks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:27:27