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Titolo:
DOPAMINE D-4 RECEPTORS AND EFFECTS OF GUANINE-NUCLEOTIDES ON [H-3] RACLOPRIDE BINDING IN POSTMORTEM CAUDATE-NUCLEUS OF SUBJECTS WITH SCHIZOPHRENIA OR MAJOR DEPRESSION
Autore:
SUMIYOSHI T; STOCKMEIER CA; OVERHOLSER JC; THOMPSON PA; MELTZER HY;
Indirizzi:
UNIV CLEVELAND HOSP,BIOL PSYCHIAT LAB,HANNA PAVILL,11100 EUCLID AVE CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT PSYCHIAT CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT PSYCHOL CLEVELAND OH 44106
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 681, anno: 1995,
pagine: 109 - 116
SICI:
0006-8993(1995)681:1-2<109:DDRAEO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; POSITRON EMISSION TOMOGRAPHY; G-PROTEINS GI; ADENYLATE-CYCLASE; H-3 QUINPIROLE; D4 RECEPTORS; HUMAN-BRAIN; RAT-BRAIN; D2; CLOZAPINE;
Keywords:
SCHIZOPHRENIA; D-4-DOPAMINE RECEPTOR; GUANINE NUCLEOTIDE; GPP(NH)P; HUMAN BRAIN; [H-3] RACLOPRIDE; [H-3] YM-09151-2; MAJOR DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
T. Sumiyoshi et al., "DOPAMINE D-4 RECEPTORS AND EFFECTS OF GUANINE-NUCLEOTIDES ON [H-3] RACLOPRIDE BINDING IN POSTMORTEM CAUDATE-NUCLEUS OF SUBJECTS WITH SCHIZOPHRENIA OR MAJOR DEPRESSION", Brain research, 681(1-2), 1995, pp. 109-116

Abstract

The densities of dopamine-D-4 receptors were determined in postmortemsamples of caudate nucleus from patients with schizophrenia (n = 9) and age-matched controls (n = 10). D-4 receptor binding was defined as the difference between binding sites labeled by [H-3]YM-09151-2 (D-2 D-3 + D-4 receptors) and those by [H-3]raclopride, in the presence of5'-guanylylimidodiphosphate (Gpp(NH)p) (D-2 + D-3 receptors). D-4 receptor binding was measurable in all the subjects with schizophrenia (mean = 3.8 pmol/g tissue) but only in 3/10 controls. To determine the specificity of these findings for schizophrenia, D-4 receptor binding was also measured in the caudate nucleus of suicide victims with major depression (n = 6) and age-matched controls (n = 6). A small amount ofD-4 binding was noted in some of the controls + depressed subjects and there was no significant difference between controls and patients with major depression. The addition of 200 mu M Gpp(NH)p to the assay significantly increased the amount of specific binding of [H-3]raclopride in control tissues, but not in tissues from subjects with schizophrenia, suggesting an abnormality in the G-protein component coupled to the D-2 receptor. [H-3]Raclopride binding was also significantly increased by Gpp(NH)p in subjects with major depression. These results confirm a previous report of Seeman et al. (1993) and suggest that measurable D-4 receptor binding in the caudate nucleus is more frequent in patients with schizophrenia as compared with normal controls and subjectswith major depression and that guanine nucleotides do not enhance [H-3]raclopride binding in schizophrenia. Further study is needed to determine if D-4 binding is increased and if an abnormality in the G-protein component coupled to the D-2 receptor is present in other brain areas in schizophrenia.

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Documento generato il 19/02/20 alle ore 15:30:46