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Titolo:
METABOLIC DISRUPTIONS IN THE ADIPOCYTE-HEPATOCYTE FATTY-ACID AXIS AS CAUSES OF HYPERAPOB
Autore:
SNIDERMAN AD; CIANFLONE K;
Indirizzi:
MCGILL UNIV,ROYAL VICTORIA HOSP,MCGILL UNIT PREVENT CARDIOVASC DIS,687 PINE AVE W MONTREAL PQ H3A 1A1 CANADA
Titolo Testata:
International journal of obesity
, volume: 19, anno: 1995, supplemento:, 1
pagine: 27 - 33
SICI:
0307-0565(1995)19:<27:MDITAF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; FAMILIAL COMBINED HYPERLIPIDEMIA; ACYLATION-STIMULATING PROTEIN; CORONARY-ARTERY DISEASE; APOLIPOPROTEIN-B SECRETION; HUMAN ADIPOSE-TISSUE; HEPG2 CELLS; HYPERTRIGLYCERIDEMIC SUBJECTS; ENHANCED SUSCEPTIBILITY; MYOCARDIAL-INFARCTION;
Keywords:
HYPERAPOB; ADIPSIN; ASP; INSULIN RESISTANCE; ADIPOSE TISSUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
A.D. Sniderman e K. Cianflone, "METABOLIC DISRUPTIONS IN THE ADIPOCYTE-HEPATOCYTE FATTY-ACID AXIS AS CAUSES OF HYPERAPOB", International journal of obesity, 19, 1995, pp. 27-33

Abstract

HyperapoB is the atherogenic dyslipoproteinemia characterized by increased numbers of LDL particles in plasma due to increased secretion ofB100 lipoprotein particles by the liver. The lipid phenotype in affected patients is variable but an increased plasma apoB points to the increased LDL particle number. The adipocyte-hepatocyte fatty acid axis refers to the traffic in fatty acids from adipocytes to hepatocytes and back again. Our central thesis is that a reduced rate of adipocyte triglyceride synthesis leads to increased traffic to and fro along thisaxis. This article outlines the ways in which impaired adipose tissuefunction leads to increased flux of fatty acids to the liver which leads, in turn, to increased secretion of hepatic B100 particles. The Adipsin-ASP pathway is a newly described biological pathway which appears to play a critical role in regulating adipose tissue triglyceride synthesis. Impaired function of this pathway appears to be the commonestreason for the increased fatty acid traffic in the adipocyte-hepatocyte axis leading to HyperapoB.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:23:44