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Titolo:
VASCULAR MORPHOLOGY AND ANGIOGENESIS IN GLIAL TUMORS
Autore:
PLATE KH; MENNEL HD;
Indirizzi:
KLINIKUM PHILIPPS UNIV,NEUROPATHOL ABT,BALDINGERSTR 1 D-35043 MARBURGGERMANY KLINIKUM PHILIPPS UNIV,NEUROPATHOL ABT D-35043 MARBURG GERMANY
Titolo Testata:
Experimental and toxicologic pathology
fascicolo: 2-3, volume: 47, anno: 1995,
pagine: 89 - 94
SICI:
0940-2993(1995)47:2-3<89:VMAAIG>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; HUMAN-BRAIN-TUMORS; MONOCLONAL-ANTIBODY KI-67; FACTOR MESSENGER-RNA; GLIOBLASTOMA-MULTIFORME; HUMAN GLIOMAS; INTRACRANIAL TUMORS; SMOOTH-MUSCLE; CELLS; PROGRESSION;
Keywords:
BRAIN TUMOR CLASSIFICATION; GLIOMA PROGRESSION; GLIOMA VASCULATURE; MORPHOMETRY OF GLIOMA VASCULARIZATION; ANGIOGENESIS; ENDOTHELIAL CELL GROWTH FACTORS IN GLIOMAS; VEGF AND VEGF RECEPTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
K.H. Plate e H.D. Mennel, "VASCULAR MORPHOLOGY AND ANGIOGENESIS IN GLIAL TUMORS", Experimental and toxicologic pathology, 47(2-3), 1995, pp. 89-94

Abstract

Intracranial tumor classification is paralleled by a grading system that empirically compares tumor entities with ''progression stages'' ofsupratentorial gliomas of the adult. This grading system is an integral part of the WHO classification. Glioma progression has originally been defined by descriptive morphology. In this respect, morphological key features of high-grade gliomas (WHO grades III and IV) are microvascular proliferation and the formation of tumor necroses. Glioma progression is now more accurately defined on the molecular genetic level by a stepwise accumulation of oncogene activation and/or tumor suppressor gene inactivation. Angiogenesis occures during development and progression of glial tumors. Pathological vessels are a hallmark of malignant glioma and it has therefore been suggested that malignant glioma cells are able to induce neovascularization. Despite the exuberant neovascularisation, however, vascular supply may not be sufficient for tumor areas with high cell proliferation, and necroses may develop. Malignant transformation of blood vessel itself is a rare event but may be the underlying mechanism of gliosarcoma development. The recently purified vascular endothelial growth factor (VEGF) is at present the only mitogen known to selectively act on endothelial cells. Growing evidence suggests that VEGF is the key regulator of developmental and pathological angiogenesis. In vivo, VEGF mRNA is upregulated in a subpopulation of malignant glioma cells adjacent to necroses. Since VEGF is hypoxia-inducible, hypoxia may be an important regulator of VEGF mRNA expression and tumor angiogenesis in vivo. Two tyrosine kinase receptors for VEGF are expressed in vessels which invade the tumor, suggesting that tumor angiogenesis is regulated by a paracrine mechanism. The analysis of mechanisms which regulate tumor and/or hypoxia induced angiogenesis can be of importance for the biology, diagnosis and treatment of both ischemic and neoplastic diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 09:37:53