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Titolo:
SALICYLALDOXIME BLOCKS K+ AND CA2+ CURRENTS IN RAT CARDIAC MYOCYTES
Autore:
KARHU S; PERTTULA S; WECKSTROM M; KIVISTO T; SELLIN LC;
Indirizzi:
UNIV OULU,DEPT PHYS SCI,DIV BIOPHYS SF-90570 OULU FINLAND UNIV OULU,DEPT PHYS SCI,DIV BIOPHYS SF-90570 OULU FINLAND UNIV OULU,DEPT PHYSIOL SF-90220 OULU FINLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 279, anno: 1995,
pagine: 7 - 13
SICI:
0014-2999(1995)279:1<7:SBKACC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT OUTWARD CURRENT; VENTRICULAR ARRHYTHMIAS; MYOCARDIAL ISCHEMIA; POTASSIUM CHANNELS; REPERFUSION; ENDOCARDIUM; EPICARDIUM; CALCIUM; INFARCTION; MECHANISMS;
Keywords:
ANTIARRHYTHMIC; ACTION POTENTIAL; CA2+ CURRENT; K+ CURRENT; OXIME; CARDIAC MYOCYTE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
S. Karhu et al., "SALICYLALDOXIME BLOCKS K+ AND CA2+ CURRENTS IN RAT CARDIAC MYOCYTES", European journal of pharmacology, 279(1), 1995, pp. 7-13

Abstract

The effects of salicylaldoxime, 2-(OH)C6H4CH = NOH, on the action potential duration, transient outward K+ current and slow inward Ca2+ current were studied in isolated rat ventricular myocytes. The application of salicylaldoxime (0.1-2.0 mM) reversibly increased the action potential duration and reduced in a dose-dependent manner both the transient outward K+ and the slow inward Ca2+ currents. The effect of salicylaldoxime on these two ionic currents was similar to that of 2,3-butanedione monoxime, but was about ten times more potent. Compounds which block both K+ and Ca2+ currents may represent a new type of Class III antiarrhythmic agent which counteracts arrhythmias initiated by re-entry with reduced proarrhythmic risk via triggered activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:39:15