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Titolo:
COCAINE DIFFERENTIALLY REGULATES ACTIVATOR PROTEIN-1 MESSENGER-RNA LEVELS AND DNA-BINDING COMPLEXES IN THE RAT STRIATUM AND CEREBELLUM
Autore:
COUCEYRO P; POLLOCK KM; DREWS K; DOUGLASS J;
Indirizzi:
OREGON HLTH SCI UNIV,VOLLUM INST,L474,3181 SAM JACKSON PK RD PORTLANDOR 97201 OREGON HLTH SCI UNIV,VOLLUM INST PORTLAND OR 97201
Titolo Testata:
Molecular pharmacology
fascicolo: 4, volume: 46, anno: 1994,
pagine: 667 - 676
SICI:
0026-895X(1994)46:4<667:CDRAPM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
D1 DOPAMINE RECEPTOR; C-FOS; NERVOUS-SYSTEM; MESSENGER-RNA; GENE-EXPRESSION; AMPHETAMINE; SENSITIZATION; TRANSPORTER; MK-801; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
P. Couceyro et al., "COCAINE DIFFERENTIALLY REGULATES ACTIVATOR PROTEIN-1 MESSENGER-RNA LEVELS AND DNA-BINDING COMPLEXES IN THE RAT STRIATUM AND CEREBELLUM", Molecular pharmacology, 46(4), 1994, pp. 667-676

Abstract

Cocaine is a psychomotor stimulant that exerts many of its behavioraland physiological effects through alteration of catecholamine reuptake systems. One early cellular response to cocaine administration is a brain region-specific alteration in the transcriptional pattern of immediate early genes belonging to the Fos/Jun family of nucleotide sequence-specific [activator protein-1 (AP-1)] DNA-binding proteins. The work described here compares cocaine-induced transcriptional regulation of immediate early gene mRNA levels, as well as AP-1 DNA-binding activity, within the striatum and cerebellum. In the striatum, acute cocaine administration increases cellular levels of c-fos and jun-B mRNA, whereas transcriptional effects in the cerebellum are limited to c-fos mRNA. After chronic cocaine treatment a desensitization of c-fos mRNA induction is observed in the striatum, with sensitization of the same transcriptional effect occurring in the cerebellum. Pharmacological studies further reveal that the dopamine D1, dopamine D2, gamma-aminobutyric acid type B, and N-methyl-D-aspartate receptor systems mediate theeffects of cocaine on cerebellar neurons, whereas striatal effects are modulated through D1 and N-methyl-D-aspartate receptors. Gel retention analysis using antibodies to the various Fos and Jun proteins was used to characterize cocaine-dependent alterations in the composition of striatal and cerebellar AP-1 DNA-binding complexes. In striatum, cocaine increases the relative levels of c-Fos, Fos-B, Jun-B, and Jun-D proteins that bind the AP-1 DNA sequence element, whereas in the cerebellum only c-Fos and Jun-D binding activities are increased. These datasuggest two possible neuroanatomical sites where tolerance and sensitization to cocaine can be examined at the genomic level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:14:03