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Titolo:
ACUTE EFFECT OF LOW-CALORIE AND LOW-CARBOHYDRATE DIET ON SERUM TRIIODOTHYRONINE-RESPONSE TO GLUCOSE-INGESTION AND ITS RELATION TO GLUCOSE-TOLERANCE
Autore:
KOH H; TSUSHIMA M; WAKI M; MATSUYAMA T;
Indirizzi:
NATL CARDIOVASC CTR,DEPT INTERNAL MED,DIV ATHEROSCLEROSIS & METAB,5-7-1 FUJISHIRO DAI SUITA OSAKA 565 JAPAN
Titolo Testata:
Hormone and Metabolic Research
fascicolo: 10, volume: 26, anno: 1994,
pagine: 470 - 473
SICI:
0018-5043(1994)26:10<470:AEOLAL>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID-HORMONE METABOLISM; INSULIN; RAT; GLUCAGON; BINDING; PROTEIN;
Keywords:
SERUM T-3-RESPONSE TO GLUCOSE INGESTION; GLUCOSE TOLERANCE; LOW-CALORIE AND LOW-CARBOHYDRATE DIET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
H. Koh et al., "ACUTE EFFECT OF LOW-CALORIE AND LOW-CARBOHYDRATE DIET ON SERUM TRIIODOTHYRONINE-RESPONSE TO GLUCOSE-INGESTION AND ITS RELATION TO GLUCOSE-TOLERANCE", Hormone and Metabolic Research, 26(10), 1994, pp. 470-473

Abstract

This study was conducted to elucidate the mechanism of glucose intolerance due to carbohydrate restriction. 15 non-diabetic patients, aged 51+/-3 yr, were placed under dietary condition-I (2,012 kcal/day; carbohydrate 299 g) for more than 3 days after admission and then condition-I was substituted by condition-II (1,156 kcal/day; carbohydrate 139 g) for 2 weeks. At the end of condition-I and -II, 75 g OGTT was performed. After the comparison between condition-I and -II, patients were subdivided into two groups, namely, glucose tolerance-improved (n = 8)and -impaired (n = 7) groups. In the former, Sigma glucose (mg/dl) during OGTT decreased from 898.1+/-28.0 to 738.5+/-36.0 (p<0.05) and Sigma IRI (mu U/ml) decreased from 418.8+/-60.1 to 300.7+/-33.5 (p<0.05) but Sigma dT(3) (ng/dl) increased from 11.3+/-14.7 to 70.3+/-15.1 (p<0.05). In the latter, Sigma glucose (mg/dl) increased from 774.6+/-46.6to 867.1+/-50.1 (p<0.05) and Sigma IRI (mu U/ml) increased from 323.4/-47.8 to 400.8+/-47.8 (p<0.05) but Sigma dT(3) (ng/dl) decreased from 45.3+/-7.1 to 20.0+/-14.7 although it did not reach a level of statistical significance. These results suggest that blunted serum T-3-response to glucose ingestion is linked to the mechanism of glucose intolerance due to carbohydrate restriction.

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Documento generato il 26/09/20 alle ore 18:05:14