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Titolo:
ON N-ACETYLCYSTEINE .1. EXPERIMENTAL AND THEORETICAL APPROACHES OF THE N-ACETYLCYSTEINE H2O2 COMPLEXATION
Autore:
ARROUB J; BERGES J; ABEDINZADEH Z; LANGLET J; GARDESALBERT M;
Indirizzi:
UNIV PARIS 06,4 PL JUSSIEU F-75005 PARIS FRANCE UNIV PARIS 06 F-75005 PARIS FRANCE UNIV PARIS 05,CHIM PHYS LAB F-75270 PARIS 06 FRANCE
Titolo Testata:
Canadian journal of chemistry
fascicolo: 10, volume: 72, anno: 1994,
pagine: 2094 - 2101
SICI:
0008-4042(1994)72:10<2094:ON.EAT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROGEN-PEROXIDE; GLUTATHIONE; REPLICATION; CYSTEINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
J. Arroub et al., "ON N-ACETYLCYSTEINE .1. EXPERIMENTAL AND THEORETICAL APPROACHES OF THE N-ACETYLCYSTEINE H2O2 COMPLEXATION", Canadian journal of chemistry, 72(10), 1994, pp. 2094-2101

Abstract

The complexation of N-acetylcysteine (RSH) with hydrogen peroxide hasbeen studied experimentally and theoretically. Experimentally we havemeasured the evolution of RSH, H2O2, and RSSR (N-acetylcystine) as a function of time. Surprisingly, H2O2 decays by a biphasic process, which is not the case for RSH and RSSR. In the first stage of the kinetics, H2O2 disappears without oxidizing the thiol function of RSH. By analogy with glutathione (GSH), the formation of a complex between RSH and H2O2 has been proposed. The thermodynamic equilibrium constant of complex formation has been determined. Theoretical calculations were performed within the SIBFA method to pinpoint the sites of complexation in isolated and hydrated states. A mixed ''discrete-continuum'' model was used to evaluate the solvent effect. The two stable complexes foundin isolated state have different behaviour under the influence of thesolvent. Comparison with complexed GSH is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:31:47