Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DIFFERENT EFFECTS ON RAT ARTERIAL-PRESSURE AND HEART-RATE WHEN LOSARTAN IS INJECTED INTO THE 3RD-VENTRICLE OR 4TH-VENTRICLE
Autore:
DELUCA LA; BARBOSA SP; MENANI JV; CAMARGO LAA; SAAD WA; RENZI A;
Indirizzi:
UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL BR-14801903 ARARAQUARA BRAZIL
Titolo Testata:
Brazilian journal of medical and biological research
fascicolo: 11, volume: 27, anno: 1994,
pagine: 2681 - 2687
SICI:
0100-879X(1994)27:11<2681:DEORAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; ANGIOTENSIN-II; BLOOD-PRESSURE; RESPONSES; DUP-753;
Keywords:
ANGIOTENSIN; LOSARTAN; BLOOD PRESSURE; HEART RATE; CEREBRAL VENTRICLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
L.A. Deluca et al., "DIFFERENT EFFECTS ON RAT ARTERIAL-PRESSURE AND HEART-RATE WHEN LOSARTAN IS INJECTED INTO THE 3RD-VENTRICLE OR 4TH-VENTRICLE", Brazilian journal of medical and biological research, 27(11), 1994, pp. 2681-2687

Abstract

Cardiovascular responses to central losartan (LOS), a non-peptide angiotensin II (ANG II) receptor antagonist, were investigated by comparing the effects of LOS injection into the 3rd and 4th cerebral ventricles (3rdV, 4thV) on mean arterial pressure (MAP) and heart rate (HR). Adult male Holtzman rats were used (N = 6 animals per group). Average basal MAP and HR were 114 +/- 3 mmHg and 343 +/- 9 bpm (N = 23), respectively. LOS (50, 100 or 200 nmol/2 mu l) injected into the 3rdV induced presser (peak of 25 +/- 3 mmHg) and tachycardic (peak of 60 +/- 25 bpm) responses. LOS injected into the 4thV had no effect on MAP, but itinduced bradycardia (peak of -35 +/- 15 bpm). KCl (200 nmol/2 mu l) injected into the 3rdV or into the 4thV had no effect on either MAP or HR compared to 0.9% saline injection. The results indicate that LOS injected into the third ventricle acts on forebrain structures to induceits presser and tachycardic effects and that bradycardia, likely dependent on hindbrain structures, is obtained when LOS is injected into the fourth ventricle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 11:00:20