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Titolo:
THE EFFECTS OF TYPICAL AND ATYPICAL ANTIPSYCHOTIC-DRUGS ON NEUROTENSIN-CONTAINING NEURONS IN THE CENTRAL-NERVOUS-SYSTEM
Autore:
KINKEAD B; NEMEROFF CB;
Indirizzi:
EMORY UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI ATLANTA GA 30322 EMORY UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI ATLANTA GA 30322
Titolo Testata:
The Journal of clinical psychiatry
fascicolo: 9, volume: 55, anno: 1994, supplemento:, B
pagine: 30 - 32
SICI:
0160-6689(1994)55:9<30:TEOTAA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC NEUROLEPTIC TREATMENT; PRONEUROTENSIN MESSENGER-RNA; RAT SUBSTANTIA-NIGRA; NUCLEUS-ACCUMBENS; HALOPERIDOL; BRAIN; RECEPTOR; EXPRESSION; TERM; BMY-14802;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
B. Kinkead e C.B. Nemeroff, "THE EFFECTS OF TYPICAL AND ATYPICAL ANTIPSYCHOTIC-DRUGS ON NEUROTENSIN-CONTAINING NEURONS IN THE CENTRAL-NERVOUS-SYSTEM", The Journal of clinical psychiatry, 55(9), 1994, pp. 30-32

Abstract

Several lines of evidence, including the effect of antipsychotic drugs on neurotensin-containing neurons, have implicated the neurotensin system in the mechanism of action of antipsychotic drugs. Thus far, allclinically efficacious antipsychotics have been found to increase neurotensin concentrations in the nucleus accumbens; ''typical'' antipsychotic drugs increase neurotensin concentrations in both the nucleus accumbens and the caudate nucleus, whereas ''atypical'' antipsychotics increase neurotensin concentrations only in the nucleus accumbens may be antipsychotic drugs on neurotensin-containing neurons in the nucleusaccumbens may be predictive of clinical antipsychotic efficacy whereas the effects on neurotensin in the caudate nucleus may be predictive of extrapyramidal side effects. In addition to this evidence that antipsychotic drugs may act at least in part on neurotensin-containing neurons to produce their clinical effects is a considerable data base indicating that there are alterations in neurotensin-containing neurons in schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:03:59