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Titolo:
THE ROLE OF 5-HT(3)-LIKE RECEPTORS IN THE ACTION OF CLOZAPINE
Autore:
WANG RY; ASHBY CR; EDWARDS E; ZHANG JY;
Indirizzi:
SUNY STONY BROOK,DEPT PSYCHIAT & BEHAV SCI STONY BROOK NY 11794 BROOKHAVEN NATL LAB,DEPT MED UPTON NY 11973 UNIV MARYLAND,DEPT PHARMACEUT SCI BALTIMORE MD 21201
Titolo Testata:
The Journal of clinical psychiatry
fascicolo: 9, volume: 55, anno: 1994, supplemento:, B
pagine: 23 - 26
SICI:
0160-6689(1994)55:9<23:TRO5RI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; 5-HT3 RECOGNITION SITES; RAT-BRAIN; RADIOLIGAND BINDING; NUCLEUS-ACCUMBENS; CEREBRAL-CORTEX; AGONIST; HYDROLYSIS; DOPAMINE; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
R.Y. Wang et al., "THE ROLE OF 5-HT(3)-LIKE RECEPTORS IN THE ACTION OF CLOZAPINE", The Journal of clinical psychiatry, 55(9), 1994, pp. 23-26

Abstract

The serotonin3 (5-HT3)-like receptors play an important role in modulating the inhibitory action of dopamine in the mesocorticolimbic regions. The atypical antipsychotic drugs clozapine and RMI 81,582, but notother antipsychotic drugs, blocked the suppressant action produced bythe 5-HT3 receptor agonist 2-methyl-5-HT on the firing rate of medialprefrontal cortical cells. Since the localization of 5-HT3 receptors overlaps with the mesocorticolimbic but not the nigrostriatal dopaminesystem, it is hypothesized that the preferential action of clozapine on the mesocorticolimbic dopamine system is the result of the drug's interaction with the 5-HT3-like receptors. Furthermore, the antagonizing effect of clozapine to 5-HT3-like receptors may contribute to its increased antipsychotic efficacy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:29:25