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Titolo:
EFFICIENT NEUTRALIZATION OF PRIMARY ISOLATES OF HIV-1 BY A RECOMBINANT HUMAN MONOCLONAL-ANTIBODY
Autore:
BURTON DR; PYATI J; KODURI R; SHARP SJ; THORNTON GB; PARREN PWHI; SAWYER LSW; HENDRY RM; DUNLOP N; NARA PL; LAMACCHIA M; GARRATTY E; STIEHM ER; BRYSON YJ; CAO YZ; MOORE JP; HO DD; BARBAS CF;
Indirizzi:
SCRIPPS CLIN & RES INST,DEPT IMMUNOL,10666 N TORREY PINES RD LA JOLLACA 92037 SCRIPPS CLIN & RES INST,DEPT BIOL MOLEC LA JOLLA CA 92037 RW JOHNSON PHARMACEUT RES INST SAN DIEGO CA 92121 CALIF DEPT HLTH SERV,VIRAL & RICKETTSIAL DIS LAB BERKELEY CA 94704 NCI,FREDERICK CANC RES & DEV CTR,TUMOR CELL BIOL LAB,VIRUS BIOL SECT FREDERICK MD 21702 UNIV CALIF LOS ANGELES,SCH MED,DEPT PEDIAT LOS ANGELES CA 90024 NYU,SCH MED,AARON DIAMOND AIDS RES CTR NEW YORK NY 10016
Titolo Testata:
Science
fascicolo: 5187, volume: 266, anno: 1994,
pagine: 1024 - 1027
SICI:
0036-8075(1994)266:5187<1024:ENOPIO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; SOLUBLE CD4; COMBINATORIAL LIBRARIES; TYPE-1; GP120; ASSAY; VACCINE; BINDING; GP160; GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
D.R. Burton et al., "EFFICIENT NEUTRALIZATION OF PRIMARY ISOLATES OF HIV-1 BY A RECOMBINANT HUMAN MONOCLONAL-ANTIBODY", Science, 266(5187), 1994, pp. 1024-1027

Abstract

The ability of antibodies to neutralize diverse primary isolates of human immunodeficiency virus-type 1 in vitro has been questioned, with implications for the likely efficacy of vaccines. A recombinant human antibody to envelope glycoprotein gp120 was generated and used to showthat primary isolates are not refractory to antibody neutralization. The recombinant antibody neutralized more than 75 percent of the primary isolates tested at concentrations that could be achieved by passiveimmunization, for example, to interrupt maternal-fetal transmission of virus. The broad specificity and efficacy of the antibody implies the conservation of a structural feature on gp120, which could be important in vaccine design.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:07:45