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Titolo:
SERUM-LIPOPROTEINS IN ACROMEGALY BEFORE AND 6-15 MONTHS AFTER TRANSSPHENOIDAL ADENOMECTOMY
Autore:
OSCARSSON J; WIKLUND O; JAKOBSSON KE; PETRUSON B; BENGTSSON BA;
Indirizzi:
GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT INTERNAL MED,ENDOCRINE UNIT S-41345 GOTHENBURG SWEDEN GOTHENBURG UNIV,SAHLGRENSKA HOSP,WALLENBERG LAB,ENDOCRINOL & METAB RES CTR GOTHENBURG SWEDEN GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT NEUROSURG S-41345 GOTHENBURG SWEDEN GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT OTORHINOLARYNGOL S-41345 GOTHENBURG SWEDEN
Titolo Testata:
Clinical endocrinology
fascicolo: 5, volume: 41, anno: 1994,
pagine: 603 - 608
SICI:
0300-0664(1994)41:5<603:SIABA6>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE TREATMENT; TRANS-SPHENOIDAL SURGERY; ISCHEMIC-HEART-DISEASE; DENSITY-LIPOPROTEIN; MYOCARDIAL-INFARCTION; DIABETES-MELLITUS; BINDING GLOBULIN; LIPID-METABOLISM; DEFICIENT ADULTS; THYROID-FUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J. Oscarsson et al., "SERUM-LIPOPROTEINS IN ACROMEGALY BEFORE AND 6-15 MONTHS AFTER TRANSSPHENOIDAL ADENOMECTOMY", Clinical endocrinology, 41(5), 1994, pp. 603-608

Abstract

OBJECTIVES Acromegaly is a rare disorder characterized by over-secretion of GH, most often because of a pituitary adenoma. The disease is associated with disturbances in lipoprotein metabolism and an increasedcardiovascular mortality. The aim of the present study was to investigate whether treatment of acromegaly results in changes in serum concentrations of lipids and apolipoproteins, including lipoprotein(a) (Lp(a)). DESIGN Fourteen patients with clinical features of acromegaly andincreased GH secretion were studied 1-10 months before and 6-15 months after transsphenoidal adenomectomy in an open study. PATIENTS Three patients had diabetes mellitus before surgery and two of these patients had normalized serum glucose levels post-operatively. Mean and baseline plasma GH levels were determined from 24-hour GH profiles. Serum samples were taken in the morning after an overnight fast. All patientswere normocholesterolaemic, and four patients were hypertriglyceridaemic before treatment. RESULTS Mean plasma GH levels decreased from 34.5 +/- 7.4 to 2.1 +/- 0.4 mU/l (mean +/- SEM). Serum IGF-I, insulin andfree T3 levels decreased and serum SHBG concentrations increased post-operatively. There was no effect of treatment on serum cholesterol concentrations, but serum triglyceride concentrations decreased. Serum apolipoprotein (apo) B and apoE levels were unaffected by treatment. Serum apoA-I levels increased and Lp(a) levers decreased post-operatively. CONCLUSIONS Successful treatment of acromegaly, resulting in normalmean GH values (<5mU/l) and/or normal responsiveness to TRH, have beneficial effects on serum lipoproteins with increased serum apoA-I levels and decreased serum levels of triglycerides and Lp(a). These effects seem to be independent of improvement in glucose tolerance, since patients with diabetes mellitus before surgery and normal fasting blood glucose levels post-operatively had similar lipoprotein responses to treatment as those with normal fasting blood glucose levels before surgery.

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Documento generato il 04/12/20 alle ore 03:04:23