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Titolo:
A RETROSPECTIVE STUDY OF RISK-FACTORS OF AKATHISIA IN TERMINALLY ILL PATIENTS
Autore:
GATTERA JA; CHARLES BG; WILLIAMS GM; CAVENAGH JD; SMITHURST BA; LUCHJENBROERS J;
Indirizzi:
UNIV QUEENSLAND,DEPT PHARM BRISBANE QLD 4072 AUSTRALIA UNIV QUEENSLAND,SCH MED,MASTER PUBL HLTH PROGRAM ST LUCIA QLD 4067 AUSTRALIA MATER MISERICORDIAE HOSP WARATAH NSW AUSTRALIA UNIV QUEENSLAND,SCH MED,DEPT SOCIAL & PREVENT MED ST LUCIA QLD 4067 AUSTRALIA HOLY SPIRIT HOSP BRISBANE QLD AUSTRALIA
Titolo Testata:
Journal of pain and symptom management
fascicolo: 7, volume: 9, anno: 1994,
pagine: 454 - 461
SICI:
0885-3924(1994)9:7<454:ARSORO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-INDUCED AKATHISIA; NEUROLEPTIC-INDUCED AKATHISIA; SCALE;
Keywords:
PALLIATIVE CARE; AKATHISIA; EPIDEMIOLOGY; RETROSPECTIVE CASE-CONTROL STUDY; RISK FACTORS; HALOPERIDOL; PROCHLORPERAZINE; MORPHINE; PROMETHAZINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Gattera et al., "A RETROSPECTIVE STUDY OF RISK-FACTORS OF AKATHISIA IN TERMINALLY ILL PATIENTS", Journal of pain and symptom management, 9(7), 1994, pp. 454-461

Abstract

Akathisia is a distressing disorder that manifests as a state of restlessness and motor agitation. We aim to highlight the problem of akathisia to the palliative care physician by identifying and quantifying risk factors in the terminally ill. A retrospective case-control study was utilized to investigate risk factors for akathisia. Medical records of cases (N = 100) and controls (N = 365) archived in a computerizeddatabase were downloaded and risk factors determined using conditional logistic regression analyses. Exposure to pharmacologically similar drugs, such as haloperidol [odds ratio (OR), 18.4; 95% confidence interval (CI), 8.2-41.4], prochlorperazine (OR, 8.1; 95% CI, 3.0-21.8), and promethazine (OR, 3.3; 95% CI, 1.3-8.0), conferred an increased risk. Other significant variables were exposure to morphine (OR, 5.3; 95% CI, 1.9-14.2), sodium valproate (OR, 2.5; 95% CI, 1.0-6.4), and sodiumbicarbonate/tartrate (Ural) (OR, 4.2; 95% CI, 1.2-15.3). Highlightingfactors that predispose patients to akathisia emphasizes that this syndrome should not be forgotten when treating the terminally ill. A is recommended that those drugs identified should be judicially wed and carefully monitored.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:05:00