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Titolo:
P53 EXPRESSION IN OVARIAN BORDERLINE TUMORS AND STAGE-I CARCINOMAS
Autore:
KUPRYJANCZYK J; BELL DA; YANDELL DW; SCULLY RE; THOR AD;
Indirizzi:
UNIV VERMONT,COLL MED,DEPT PATHOL,A249 MED ALUMNI BLDG BURLINGTON VT 05405 HARVARD UNIV,SCH MED,DEPT PATHOL BOSTON MA 02115 MASSACHUSETTS GEN HOSP,JAMES HOMER WRIGHT LABS BOSTON MA 00000 HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL BOSTON MA 02115 MASSACHUSETTS EYE & EAR INFIRM,MOLEC GENET RES LAB BOSTON MA 02114
Titolo Testata:
American journal of clinical pathology
fascicolo: 5, volume: 102, anno: 1994,
pagine: 671 - 676
SICI:
0002-9173(1994)102:5<671:PEIOBT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICOPATHOLOGIC ANALYSIS; PAPILLARY CYSTADENOMAS; SUPPRESSOR GENE; UNIFOCAL ORIGIN; MUCINOUS TUMORS; CANCER; PROTEIN; MUTATIONS; OVEREXPRESSION; ACCUMULATION;
Keywords:
ENDOMETRIOSIS; OVARIAN BORDERLINE TUMORS; OVARIAN CARCINOMAS; P53 PROTEIN ACCUMULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J. Kupryjanczyk et al., "P53 EXPRESSION IN OVARIAN BORDERLINE TUMORS AND STAGE-I CARCINOMAS", American journal of clinical pathology, 102(5), 1994, pp. 671-676

Abstract

Seventy-nine ovarian serous and mucinous borderline tumors, 36 stage I carcinomas and 39 stage II-IV carcinomas were studied for p53 protein accumulation with monoclonal antibody PAb1801. p53 protein was expressed in 14% of borderline tumors, 36% of stage I carcinomas, and 64% of higher stage carcinomas. All immunopositive carcinomas accumulated p53 protein in the primary tumor, and 95% of them showed concordance instaining among different tissue blocks. A difference in frequency of p53 protein accumulation between stage I and higher stage serous carcinomas was not statistically significant. p53 positivity was associatedwith microinvasion, microcarcinoma and coexistent carcinoma in mucinous borderline tumors (P = .025). An association between p53 protein expression and poor tumor differentiation in Stage I carcinomas was statistically significant (P = .03). p53 positivity was observed in a poorly differentiated endometrioid carcinoma as well as in adjacent benignendometriotic tissue. These results suggest that p53 abnormalities may be early events in ovarian cancer, possibly contributing to malignant transformation of some borderline tumors, endometriosis and other carcinoma precursors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 16:21:54