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Titolo:
USE OF REVERSED-PHASE HPLC FOR DETERMINATION OF THE HYDROLYSIS RATE CONSTANTS OF DICHLORO(1,2-DIARYLETHYLENEDIAMINE)PLATINUM(II) COMPLEXES
Autore:
BEDNARSKI PJ; TRUMBACH B;
Indirizzi:
UNIV REGENSBURG,FAK CHEM PHARM,LEHRSTUHL PHARMAZEUT CHEM 2 D-93040 REGENSBURG GERMANY
Titolo Testata:
Transition metal chemistry
fascicolo: 5, volume: 19, anno: 1994,
pagine: 513 - 517
SICI:
0340-4285(1994)19:5<513:UORHFD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIXED-AMINE CISPLATIN; AQUEOUS CHEMISTRY; CIS-DICHLORODIAMMINEPLATINUM(II); PRODUCTS; RING; CIS-DIAMMINEDICHLOROPLATINUM(II); NUCLEOPHILES; KINETICS; ANALOGS; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Bednarski e B. Trumbach, "USE OF REVERSED-PHASE HPLC FOR DETERMINATION OF THE HYDROLYSIS RATE CONSTANTS OF DICHLORO(1,2-DIARYLETHYLENEDIAMINE)PLATINUM(II) COMPLEXES", Transition metal chemistry, 19(5), 1994, pp. 513-517

Abstract

The rates of the Pt-Cl hydrolysis reactions for a series of dichloro(1,2-diarylethylenediamine)platinum(II) complexes were measured by means of a reversed-phase h.p.l.c. assay. The compounds were hydrolysed atrates comparable to those published for [PtCl2(en)]. The configuration of the 1,2-diarylethylenediamine ligand (meso versus racem), as wellas the type of substituent (i.e. OMe, CN or F) in the para-position of the aromatic rings had only a marginal influence on the rates of hydrolysis; however, the introduction of ortho-chloro substituents onto the aromatic rings markedly slowed the hydrolysis reactions. In contrast to the reported pH-dependency of the hydrolysis rates of cisplatin, changes in proton concentration had no effect on the hydrolysis rates of the title compounds over a pH range of 2.2-7.2. The activation parameters Delta H-not equal and Delta S-not equal of the Pt-Cl hydrolysisrates were comparable to those reported for similar Pt-II compounds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:34:51