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Titolo:
NGF-RESPONSE OF EGF-DEPENDENT PROGENITOR CELLS OBTAINED FROM HUMAN SYMPATHETIC-GANGLIA
Autore:
SILANI V; BORASIO GD; ZHOU FC; BERNASCONI S; PIZZUTI A; SAMPIETRO A; SCARLATO G;
Indirizzi:
UNIV MILAN,DINO FERRARI CTR,INST NEUROL,VIA F SFORZA 35 I-20122 MILANITALY UNIV MUNICH,KLINIKUM GROSSHADERN,NEUROL KLIN D-81366 MUNICH GERMANY INDIANA UNIV,SCH MED,DEPT ANAT INDIANAPOLIS IN 00000
Titolo Testata:
NeuroReport
fascicolo: 16, volume: 5, anno: 1994,
pagine: 2085 - 2089
SICI:
0959-4965(1994)5:16<2085:NOEPCO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; NEURAL CREST; NEURONAL DIFFERENTIATION; CHROMAFFIN CELLS; PC12 CELLS; GLUCOCORTICOIDS; OUTGROWTH; FATE;
Keywords:
NEURAL CREST; SYMPATHETIC NEURONS; PROGENITOR CELL; NERVE GROWTH FACTOR (NGF); EPIDERMAL GROWTH FACTOR (EGF); TISSUE CULTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
V. Silani et al., "NGF-RESPONSE OF EGF-DEPENDENT PROGENITOR CELLS OBTAINED FROM HUMAN SYMPATHETIC-GANGLIA", NeuroReport, 5(16), 1994, pp. 2085-2089

Abstract

SIGNALLING molecules are thought to play a significant role in determining the fate of neural crest progenitor cells. The human sympatheticchain was identified at 6.5, 7.5, 8.2, 10.2 and 11.4 postconception (PC) weeks demonstrating low affinity nerve growth factor (NGF) receptors, and was processed for tissue culture. In the presence of epidermalgrowth factor (EGF), floating spheres of proliferating progenitor cells were developed in vitro. In the absence of EGF progenitor cells differentiated into tyrosine hydroxylase (TH)-immunoreactive neuronal andTH-negative flat cells. NGF treatment significantly increased neuriteoutgrowth and survival of TH-immunoreactive cells. The multipotent cells we isolated differ from previously reported sympathoadrenal progenitors in that they give rise to TH immunoreactive neurones precociously sensitive to NGF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:46:08