Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
AMITRIPTYLINE IN THE TREATMENT OF CHRONIC TENSION-TYPE HEADACHE
Autore:
GOBEL H; HAMOUZ V; HANSEN C; HEININGER K; HIRSCH S; LINDNER V; HEUSS D; SOYKA D;
Indirizzi:
CHRISTIAN ALBRECHTS UNIV KIEL,NEUROL KLIN,NIEMANNSWEG 147 D-24105 KIEL GERMANY
Titolo Testata:
Nervenarzt
fascicolo: 10, volume: 65, anno: 1994,
pagine: 670 - 679
SICI:
0028-2804(1994)65:10<670:AITTOC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
GER
Soggetto:
MUSCLE-CONTRACTION HEADACHE; TRICYCLIC ANTI-DEPRESSANTS; EXTEROCEPTIVE SUPPRESSION; BLIND; 5-HYDROXYTRYPTAMINE; PROPHYLAXIS; SEROTONIN; TRIAL; PAIN;
Keywords:
CHRONIC TENSION-TYPE HEADACHE; AMITRIPTYLINE; PERICRANIAL MUSCLE ACTIVITY; EXTEROCEPTIVE SUPPRESSION; CONTINGENT NEGATIVE VARIATION; PAIN MEASUREMENT; PAIN SENSITIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
H. Gobel et al., "AMITRIPTYLINE IN THE TREATMENT OF CHRONIC TENSION-TYPE HEADACHE", Nervenarzt, 65(10), 1994, pp. 670-679

Abstract

In a double-blind, placebo-controlled trial, the effect of 75 mg of aslow-release formulation of amitriptyline on the clinical severity ofchronic tension-type headache and on headache-associated neurophysiological parameters (EMG activity, exteroceptive suppression of temporalmuscle activity, contingent negative variation (CNV) and experimentalpain sensitivity) was investigated. All of the patients treated had ahistory of headaches of many years standing, and numerous failed attempts at treatment. In the amitriptyline group, a significant reductionin daily headache duration was already found in the third week of treatment, while in the placebo group no significant changes in headache duration were to be seen. In week 6 the amitriptyline group had a significantly shorter daily duration of headache than the placebo group. Treatment did not result in any significant effects on EMG recording ofpericranial muscle activity either during relaxation or contraction, on exteroceptive suppression of the temporal muscle and on CNV. The sensitivity to suprathreshold experimental pain, however, was significantly reduced. The data show a statistically relevant reduction of dailyheadache duration in chronic tension-type headache. However, they also show that amitriptyline can only partly alleviate chronic headaches but cannot cure them.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 20:24:02