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Titolo:
EARLY URINARY MARKERS OF TARGET NEPHRON SEGMENTS AS STUDIED IN CADMIUM TOXICITY
Autore:
FELS LM; BUNDSCHUH I; GWINNER W; JUNG K; PERGANDE M; GRAUBAUM HJ; PRICE RG; TAYLOR SA; DEBROE ME; NUYTS GD; MUTTI A; FRANCHINI I; LAUWERYS R; ROELS H; BERNARD A; GELPI E; ROSELLO J; HOTTER G; STOLTE H;
Indirizzi:
HANNOVER MED SCH,DIV NEPHROL EXP NEPHROL,KONSTANTY GUTSCHOW STR 8 D-30625 HANNOVER GERMANY HUMBOLDT UNIV BERLIN,UNIV HOSP CHARITE BERLIN GERMANY CTR ENVIRONM & OCCUPAT MED BERLIN GERMANY UNIV LONDON KINGS COLL,DIV BIOMOLEC SCI,BIOCHEM SECT LONDON ENGLAND UNIV ANTWERP,DIV NEPHROL HYPERTENS ANTWERP BELGIUM UNIV CATHOLIQUE LOUVAIN,UNITE TOXICOL IND & MED TRAVAIL B-1200 BRUSSELS BELGIUM UNIV PARMA,SCH MED,IND TOXICOL LAB PARMA ITALY CSIC,DEPT BIOMED ANAL,MOLEC PATHOL & BIOCHEM INFLAMMAT UNIT BARCELONASPAIN
Titolo Testata:
Kidney international
, , anno: 1994, supplemento:, 47
pagine: 81 - 88
SICI:
0085-2538(1994):<81:EUMOTN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MERCURY-VAPOR; INDUSTRIAL POLLUTANTS; ENZYME-IMMUNOASSAY; RENAL DYSFUNCTION; ANTIBODIES; INHIBITION; EXPOSURE; SERUM; LEAD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
L.M. Fels et al., "EARLY URINARY MARKERS OF TARGET NEPHRON SEGMENTS AS STUDIED IN CADMIUM TOXICITY", Kidney international, 1994, pp. 81-88

Abstract

A number of chemicals may adversely affect one or more of the anatomical structures of the kidney, such as the glomerulus, the tubular apparatus, the medullary, or interstitial cells. To recognize subclinical renal dysfunction, a battery of new, non-invasive tests was applied incomparison to established ones. The study on cadmium exposed subjects, performed within the framework of a collaborative European research project, exemplifies the concept of target selectivity within a nephron. One hundred seventy-two subjects were classified according to urinary cadmium excretion as controls (<1.5 mu g/g creatinine), or subjectswith moderate or high cadmium body burden (1.5 to 5 mu g/g creatinine, >5 mu g/g creatinine). Twenty-six urinary analytes (such as serum derived proteins, tubular enzymes, eicosanoids) and four plasma markers,related to the function or integrity of specific nephron segments, were investigated in a cross-sectional study. The group with the moderate cadmium body burden showed alterations of proximal tubular integrity, that is, increased excretion of tubular brush-border antigens. The group with higher cadmium body burden revealed an involvement of the whole nephron. The most prominent quantitative changes were found for the glomerular markers high molecular weight proteins, and thromboxane B-2 and for the proximal tubular markers retinol binding protein, alpha(1)-microglobulin, N-acetyl-beta-D-glucosaminidase, and the intestinalalkaline phosphatase. A diagnostic approach to screen for nephrotoxicity due to environmental hazards like cadmium should include proximal tubular markers (alpha(1)-microglobulin and tubular enzymes, that is, intestinal alkaline phosphatase) but the measurement of glomerular markers is also advisable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 09:43:22