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Titolo:
COMPARISON OF 2 EPIDEMIOLOGIC PROTOCOLS FOR MEASURING AIRWAY RESPONSIVENESS AND ALLERGIC SENSITIVITY IN ADULTS
Autore:
TOELLE BG; PEAT JK; SALOME CM; CRANE J; MCMILLAN D; DERMAND J; DSOUZA W; WOOLCOCK AJ;
Indirizzi:
ROYAL PRINCE ALFRED HOSP,INST RESP MED CAMPERDOWN NSW 2050 AUSTRALIA ROYAL PRINCE ALFRED HOSP,INST RESP MED CAMPERDOWN NSW 2050 AUSTRALIA WELLINGTON SCH MED,DEPT MED WELLINGTON NEW ZEALAND UNIV SYDNEY,DEPT MED SYDNEY NSW 2006 AUSTRALIA
Titolo Testata:
The European respiratory journal
fascicolo: 10, volume: 7, anno: 1994,
pagine: 1798 - 1804
SICI:
0903-1936(1994)7:10<1798:CO2EPF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL HYPERRESPONSIVENESS; RESPIRATORY SYMPTOMS; AUSTRALIAN SCHOOLCHILDREN; HISTAMINE CHALLENGE; METHACHOLINE; POPULATION; COMMUNITY; REPEATABILITY; REACTIVITY; CHILDREN;
Keywords:
ALLERGY; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; EPIDEMIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
B.G. Toelle et al., "COMPARISON OF 2 EPIDEMIOLOGIC PROTOCOLS FOR MEASURING AIRWAY RESPONSIVENESS AND ALLERGIC SENSITIVITY IN ADULTS", The European respiratory journal, 7(10), 1994, pp. 1798-1804

Abstract

In recent years, airway responsiveness has commonly been measured in epidemiological studies using one of two methods. In one method, histamine is administered via a handheld DeVilbiss nebulizer and in the other, methacholine is administered via a dosimeter. Allergic sensitivityhas commonly been measured by either the allergen droplet method or by Phazet. We wanted to assess the comparability of airway responsiveness and of allergic sensitivity measured by both methods. A total of 48volunteers, including normal and asthmatic subjects, participated in the study. Subjects first underwent one of the two tests of airway responsiveness and allergic sensitivity, and then returned within 10 daysto undergo tests using the second protocol. Commencement protocol wasallocated in random order. There was good agreement between both methods for assessing airway responsiveness and for assessing allergic sensitivity. The difference for dose response ratio (DRR) between histamine and methacholine was a 1.19 (95% (CI) 0.78, 1.82) fold changes, which was not statistically significant. Agreement between allergic sensitivity methods was perfect for Alternaria tenuis, good for rye-grass (kappa=0.71) and moderate for cat and Dermatophagoides pteronyssinus (kappa approximately 0.5). It is possible to compare data from epidemiological studies which use these methods.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 16:15:50